Expression patterns of aquaporin 1 in vascular tumours.
Adult
Aquaporin 1
/ genetics
Biomarkers, Tumor
/ genetics
Biopsy, Needle
Cohort Studies
Confidence Intervals
Diagnosis, Differential
Female
Gene Expression Regulation, Neoplastic
Hemangioma
/ genetics
Hemangiosarcoma
/ genetics
Humans
Immunohistochemistry
Male
Sarcoma, Kaposi
/ genetics
Vascular Neoplasms
/ genetics
Kaposi's sarcoma
angiosarcoma
aquaporins
infantile haemangioma
pyogenic granuloma
vascular tumour
Journal
European journal of dermatology : EJD
ISSN: 1952-4013
Titre abrégé: Eur J Dermatol
Pays: France
ID NLM: 9206420
Informations de publication
Date de publication:
01 Aug 2019
01 Aug 2019
Historique:
pubmed:
31
8
2019
medline:
19
3
2020
entrez:
31
8
2019
Statut:
ppublish
Résumé
Aquaporins (AQPs) are a family of water channels expressed in various body tissues. Beyond osmotic balance, AQPs have recently been confirmed to be involved in processes related to cancer (tumour proliferation, angiogenesis, etc.). To analyse the presence of these proteins in the endothelium of several vascular tumours, both benign and malignant, in order to establish whether AQPs may be used as a marker or future therapeutic target. We studied AQP1 expression in 39 patients with vascular tumours, classified into six groups according to ISSVA classification: haemangiomas, benign vascular tumours different from infantile haemangiomas, angiosarcomas, classic Kaposi's sarcoma (KS), and epidemic KS. AQP1 expression was present in 28 of 39 patients, representing 92.9% benign lesions, whereas no expression was found in 72% of malignant lesions. AQP1 expression was associated with benign lesions with an OR of 34.5 (95% CI: 5-250); p<0.0005, and was most frequently identified with a focal endothelial pattern (38%). A kappa index of 0.823 (95% CI: 0.678-0.971) was determined regarding the patterns of expression overall. The expression of AQP1 was greater in benign lesions than malignant lesions and this difference was statistically significant, thus AQP1 expression could serve as a marker for benignity of vascular tumours. In addition, the expression pattern of AQP1 was different according to the type of vascular tumour.
Sections du résumé
BACKGROUND
BACKGROUND
Aquaporins (AQPs) are a family of water channels expressed in various body tissues. Beyond osmotic balance, AQPs have recently been confirmed to be involved in processes related to cancer (tumour proliferation, angiogenesis, etc.).
OBJECTIVES
OBJECTIVE
To analyse the presence of these proteins in the endothelium of several vascular tumours, both benign and malignant, in order to establish whether AQPs may be used as a marker or future therapeutic target.
MATERIALS AND METHODS
METHODS
We studied AQP1 expression in 39 patients with vascular tumours, classified into six groups according to ISSVA classification: haemangiomas, benign vascular tumours different from infantile haemangiomas, angiosarcomas, classic Kaposi's sarcoma (KS), and epidemic KS.
RESULTS
RESULTS
AQP1 expression was present in 28 of 39 patients, representing 92.9% benign lesions, whereas no expression was found in 72% of malignant lesions. AQP1 expression was associated with benign lesions with an OR of 34.5 (95% CI: 5-250); p<0.0005, and was most frequently identified with a focal endothelial pattern (38%). A kappa index of 0.823 (95% CI: 0.678-0.971) was determined regarding the patterns of expression overall.
CONCLUSION
CONCLUSIONS
The expression of AQP1 was greater in benign lesions than malignant lesions and this difference was statistically significant, thus AQP1 expression could serve as a marker for benignity of vascular tumours. In addition, the expression pattern of AQP1 was different according to the type of vascular tumour.
Identifiants
pubmed: 31466938
pii: ejd.2019.3602
doi: 10.1684/ejd.2019.3602
doi:
Substances chimiques
Biomarkers, Tumor
0
Aquaporin 1
146410-94-8
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM