Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation.
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
21
12
2018
accepted:
23
08
2019
pubmed:
31
8
2019
medline:
28
4
2021
entrez:
31
8
2019
Statut:
ppublish
Résumé
Interactions between platelets, leukocytes and the vessel wall provide alternative pathological routes of thrombo-inflammatory leukocyte recruitment. We found that when platelets were activated by a range of agonists in whole blood, they shed platelet-derived extracellular vesicles which rapidly and preferentially bound to blood monocytes compared to other leukocytes. Platelet-derived extracellular vesicle binding to monocytes was initiated by P-selectin-dependent adhesion and was stabilised by binding of phosphatidylserine. These interactions resulted in the progressive transfer of the platelet adhesion receptor GPIbα to monocytes. GPIbα
Identifiants
pubmed: 31467123
pii: haematol.2018.215145
doi: 10.3324/haematol.2018.215145
pmc: PMC7193470
doi:
Substances chimiques
Platelet Glycoprotein GPIb-IX Complex
0
adhesion receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1248-1261Subventions
Organisme : British Heart Foundation
ID : AA/18/2/34218
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/19/30/34173
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/03/003
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/14/42/30956
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/12/7/29693
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/03/003/15571
Pays : United Kingdom
Informations de copyright
Copyright© 2020 Ferrata Storti Foundation.
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