Endocrine responses during CPAP withdrawal in obstructive sleep apnoea: data from two randomised controlled trials.
Obstructive sleep apnoea
cardiovascular
catecholamines
continuous positive airway pressure
sympathetic activity
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
25
04
2019
revised:
09
08
2019
accepted:
13
08
2019
pubmed:
31
8
2019
medline:
19
5
2020
entrez:
31
8
2019
Statut:
ppublish
Résumé
The aim of this investigation was to elucidate the effect of CPAP withdrawal on neurometabolic and cardiometabolic markers in patients with obstructive sleep apnoea. We evaluated 70 patients (mean age 61±10 years, 82% men) treated with CPAP in two 2-week, parallel, randomised controlled trials. CPAP withdrawal resulted in elevated 3,4-dihydroxyphenylglycol, norepinephrine and cortisol after 2 weeks of CPAP withdrawal; however, no statistically significant changes of the renin-angiotensin-aldosterone system (RAAS) determinants were documented. In summary, CPAP withdrawal may be more prominently linked to short-term increases in sympathetic activation than hypothalamic-pituitary-adrenal axis or RAAS activation. ClinicalTrials.gov Identifier: NCT02493673 and NCT02050425.
Identifiants
pubmed: 31467191
pii: thoraxjnl-2019-213522
doi: 10.1136/thoraxjnl-2019-213522
doi:
Substances chimiques
Biomarkers
0
Methoxyhydroxyphenylglycol
534-82-7
3,4-dihydroxyphenylglycol
UEH9K539KJ
Hydrocortisone
WI4X0X7BPJ
Norepinephrine
X4W3ENH1CV
Banques de données
ClinicalTrials.gov
['NCT02493673', 'NCT02050425']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1102-1105Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: MK reports grants from University of Zurich, grants from Lunge Zurich, during the conduct of the study; grants from Bayer AG (consultancy), outside the submitted work. TG reports grants from Bayer AG (consultancy), outside the submitted work.