Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.
Journal
Neural plasticity
ISSN: 1687-5443
Titre abrégé: Neural Plast
Pays: United States
ID NLM: 100883417
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
11
2018
revised:
11
05
2019
accepted:
29
05
2019
entrez:
31
8
2019
pubmed:
31
8
2019
medline:
28
7
2020
Statut:
epublish
Résumé
One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations in low frequency signal are reported, but it is unknown if interactions are present between the level of depressive symptom score and intrinsic brain activity in varying brain regions. To investigate potential interaction effects between whole-brain resting-state activity and depressive symptoms in stroke survivors with low and high levels of depressive symptoms. A cross-sectional analysis of 63 stroke survivors who were assessed at 3 months poststroke for depression, using the Montgomery-Åsberg Depression Rating Scale (MÅDRS-SIGMA), and for brain activity using fMRI. A MÅDRS-SIGMA score of >8 was classified as high depressive symptoms. Fractional amplitude of frequency fluctuations (fALFF) data across three frequency bands (broadband, i.e., ~0.01-0.08; subbands, i.e., slow-5: ~0.01-0.027 Hz, slow-4: 0.027-0.07) was examined. Of the 63 stroke survivors, 38 were classified as "low-depressive symptoms" and 25 as "high depressive symptoms." Six had a past history of depression. We found interaction effects across frequency bands in several brain regions that differentiated the two groups. The broadband analysis revealed interaction effects in the left insula and the left superior temporal lobe. The subband analysis showed contrasting fALFF response between the two groups in the left thalamus, right caudate, and left cerebellum. Across the three frequency bands, we found contrasting fALFF response in areas within the fronto-limbic-thalamic network and cerebellum. We provide evidence that fALFF is sensitive to changes in poststroke depressive symptom severity and implicates frontostriatal and cerebellar regions, consistent with previous studies. The use of multiband analysis could be an effective method to examine neural correlates of depression after stroke. The START-PrePARE trial is registered with the Australian New Zealand Clinical Trial Registry, number ACTRN12610000987066.
Sections du résumé
Background
One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations in low frequency signal are reported, but it is unknown if interactions are present between the level of depressive symptom score and intrinsic brain activity in varying brain regions.
Objective
To investigate potential interaction effects between whole-brain resting-state activity and depressive symptoms in stroke survivors with low and high levels of depressive symptoms.
Methods
A cross-sectional analysis of 63 stroke survivors who were assessed at 3 months poststroke for depression, using the Montgomery-Åsberg Depression Rating Scale (MÅDRS-SIGMA), and for brain activity using fMRI. A MÅDRS-SIGMA score of >8 was classified as high depressive symptoms. Fractional amplitude of frequency fluctuations (fALFF) data across three frequency bands (broadband, i.e., ~0.01-0.08; subbands, i.e., slow-5: ~0.01-0.027 Hz, slow-4: 0.027-0.07) was examined.
Results
Of the 63 stroke survivors, 38 were classified as "low-depressive symptoms" and 25 as "high depressive symptoms." Six had a past history of depression. We found interaction effects across frequency bands in several brain regions that differentiated the two groups. The broadband analysis revealed interaction effects in the left insula and the left superior temporal lobe. The subband analysis showed contrasting fALFF response between the two groups in the left thalamus, right caudate, and left cerebellum. Across the three frequency bands, we found contrasting fALFF response in areas within the fronto-limbic-thalamic network and cerebellum.
Conclusions
We provide evidence that fALFF is sensitive to changes in poststroke depressive symptom severity and implicates frontostriatal and cerebellar regions, consistent with previous studies. The use of multiband analysis could be an effective method to examine neural correlates of depression after stroke. The START-PrePARE trial is registered with the Australian New Zealand Clinical Trial Registry, number ACTRN12610000987066.
Identifiants
pubmed: 31467520
doi: 10.1155/2019/2357107
pmc: PMC6701282
doi:
Banques de données
ClinicalTrials.gov
['NCT00887328']
ANZCTR
['ACTRN12610000987066']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2357107Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
Références
Int J Stroke. 2014 Dec;9(8):1017-25
pubmed: 25117911
Front Neuroinform. 2011 Aug 22;5:13
pubmed: 21897815
Stroke. 2004 Mar;35(3):794-802
pubmed: 14963278
Multivariate Behav Res. 2005;40(3):373-400
pubmed: 26794689
Perspect Biol Med. 2001 Fall;44(4):522-42
pubmed: 11600799
Depress Anxiety. 2001;13(1):32-7
pubmed: 11233458
J Abnorm Psychol. 2000 May;109(2):345-51
pubmed: 10895574
Nat Rev Neurol. 2012 Dec;8(12):711-6
pubmed: 23070610
J Psychosom Res. 2009 Oct;67(4):325-32
pubmed: 19773025
Brain Connect. 2013;3(4):339-52
pubmed: 23705677
J Neurol. 2015 Jan;262(1):81-90
pubmed: 25308633
Front Hum Neurosci. 2013 Apr 02;7:118
pubmed: 23565090
PLoS One. 2012;7(10):e48658
pubmed: 23119084
Disabil Rehabil. 2019 Oct;41(21):2548-2555
pubmed: 29889570
Behav Brain Sci. 2012 Jun;35(3):121-43
pubmed: 22617651
J Neurosci Methods. 2008 Jul 15;172(1):137-41
pubmed: 18501969
Neuroimage. 2006 Jul 15;31(4):1536-48
pubmed: 16632379
Br J Psychiatry. 2008 Jan;192(1):52-8
pubmed: 18174510
Biol Psychiatry. 2014 Oct 1;76(7):527-35
pubmed: 24462230
Neurosci Lett. 2016 Feb 12;614:105-11
pubmed: 26797652
Stroke Res Treat. 2013;2013:862978
pubmed: 23533964
Front Hum Neurosci. 2015 Jan 14;8:1045
pubmed: 25642179
Neuroimage Clin. 2017 Jul 18;16:116-124
pubmed: 28794972
Stroke. 2000 Jul;31(7):1482-6
pubmed: 10884441
J Abnorm Psychol. 2008 Feb;117(1):182-92
pubmed: 18266496
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
pubmed: 20176931
Dialogues Clin Neurosci. 2007;9(2):141-51
pubmed: 17726913
J Comp Neurol. 2005 Dec 5;493(1):154-66
pubmed: 16254997
J Cereb Blood Flow Metab. 2016 Dec;36(12):2162-2176
pubmed: 26661223
Int J Stroke. 2015 Jun;10(4):636-44
pubmed: 24206623
Psychol Med. 1999 Jan;29(1):73-85
pubmed: 10077295
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Hum Brain Mapp. 2001 Jun;13(2):55-73
pubmed: 11346886
Sci Rep. 2014 Dec 09;4:7376
pubmed: 25488025
Science. 2004 Jun 25;304(5679):1926-9
pubmed: 15218136
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neural Regen Res. 2014 Aug 1;9(15):1474-84
pubmed: 25317160
Brain Connect. 2012;2(1):25-32
pubmed: 22432927
Brain Struct Funct. 2008 Sep;213(1-2):93-118
pubmed: 18704495
Int J Geriatr Psychiatry. 2004 Nov;19(11):1053-7
pubmed: 15481073
Eur J Neurol. 2001 Jul;8(4):315-9
pubmed: 11422427
Annu Rev Clin Psychol. 2010;6:285-312
pubmed: 20192795
Neuroimage Clin. 2018 Feb 07;18:342-355
pubmed: 29487791
Brain Imaging Behav. 2017 Dec;11(6):1571-1580
pubmed: 27743373
J Stroke Cerebrovasc Dis. 2013 Oct;22(7):e124-35
pubmed: 23149149
Neuroimage. 2004 Jan;21(1):450-5
pubmed: 14741682
Neuroimage Clin. 2016 Nov 12;13:39-45
pubmed: 27942446
Neuroimage. 2013 Jan 15;65:349-63
pubmed: 23046981
J Affect Disord. 2012 Dec 15;142(1-3):6-12
pubmed: 22858266
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
Neuroimage. 2014 Dec;103:249-257
pubmed: 25251869
J Neurophysiol. 2011 Nov;106(5):2322-45
pubmed: 21795627
J Affect Disord. 2018 Feb;227:554-562
pubmed: 29169125
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
pubmed: 15939837
Neuroimage. 2012 Oct 1;62(4):2271-80
pubmed: 22414990
Brain Dev. 2007 Mar;29(2):83-91
pubmed: 16919409
Lancet. 2000 Jul 8;356(9224):122-6
pubmed: 10963248
Hum Brain Mapp. 2008 Jun;29(6):683-95
pubmed: 17598168
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
J Cereb Blood Flow Metab. 2017 Aug;37(8):2665-2678
pubmed: 28541130
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
Am J Geriatr Psychiatry. 2000 Fall;8(4):310-7
pubmed: 11069271
Neuroimage. 2010 Jan 15;49(2):1432-45
pubmed: 19782143
Trends Cogn Sci. 2012 Jan;16(1):61-71
pubmed: 22197477
Ann Neurol. 1993 Feb;33(2):181-9
pubmed: 8434880
Stroke. 1999 Sep;30(9):1875-80
pubmed: 10471439
Neuroimage. 2012 Jul 2;61(3):677-85
pubmed: 22521254
J Mol Psychiatry. 2013 Aug 23;1(1):14
pubmed: 25408907
Int J Stroke. 2017 Jul;12(5):480-493
pubmed: 28697711
Int J Methods Psychiatr Res. 2003;12(1):3-21
pubmed: 12830306
Nat Rev Neurol. 2016 Jan;12(1):28-39
pubmed: 26670297
Neuroimage. 2011 Feb 1;54(3):2033-44
pubmed: 20851191
J Med Life. 2010 Jul-Sep;3(3):216-20
pubmed: 20945810
Nature. 2001 Jul 12;412(6843):150-7
pubmed: 11449264
Stroke. 1989 Jul;20(7):864-70
pubmed: 2749846
Ann N Y Acad Sci. 1999 Jun 29;877:614-37
pubmed: 10415674
Biomed Res Int. 2014;2014:846830
pubmed: 24963485
Nat Rev Neurosci. 2007 Sep;8(9):700-11
pubmed: 17704812
Stroke. 2005 Jun;36(6):1330-40
pubmed: 15879342
Front Neuroanat. 2012 Aug 10;6:31
pubmed: 22907994
Am J Psychiatry. 2016 Mar 1;173(3):221-31
pubmed: 26684921
PLoS One. 2007 Feb 28;2(2):e259
pubmed: 17327919
Neuroimage. 2013 Aug 1;76:183-201
pubmed: 23499792
Pharmacol Ther. 2018 Apr;184:131-144
pubmed: 29128343
Am J Psychiatry. 2008 Aug;165(8):969-77
pubmed: 18628348
Radiology. 2012 Jul;264(1):218-24
pubmed: 22668562
Hum Brain Mapp. 2009 Aug;30(8):2530-41
pubmed: 19072895
Magn Reson Med. 1996 Mar;35(3):346-55
pubmed: 8699946
Front Hum Neurosci. 2012 Dec 03;6:323
pubmed: 23227005
Disabil Rehabil. 1993 Apr-Jun;15(2):55-66
pubmed: 8513158
Am J Public Health. 2005 Jun;95(6):998-1000
pubmed: 15914823
AJNR Am J Neuroradiol. 2000 Oct;21(9):1636-44
pubmed: 11039342
J Cogn Neurosci. 2010 Dec;22(12):2790-803
pubmed: 20044897