Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals.
HTLV-1
antiretroviral drugs
myelopathy
screening
transplantation
Journal
Therapeutic advances in infectious disease
ISSN: 2049-9361
Titre abrégé: Ther Adv Infect Dis
Pays: England
ID NLM: 101606715
Informations de publication
Date de publication:
Historique:
received:
26
04
2019
accepted:
16
07
2019
entrez:
31
8
2019
pubmed:
31
8
2019
medline:
31
8
2019
Statut:
epublish
Résumé
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor-recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.
Identifiants
pubmed: 31467675
doi: 10.1177/2049936119868028
pii: 10.1177_2049936119868028
pmc: PMC6704407
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2049936119868028Investigateurs
C Rodríguez
(C)
M Vera
(M)
J Del Romero
(J)
G Marcaida
(G)
M D Ocete
(MD)
E Caballero
(E)
I Molina
(I)
A Aguilera
(A)
J J Rodríguez-Calviño
(JJ)
D Navarro
(D)
C Rivero
(C)
M D Vilariño
(MD)
R Benito
(R)
S Algarate
(S)
J Gil
(J)
R Ortiz de Lejarazu
(R)
S Rojo
(S)
J M Eirós
(JM)
A San Miguel
(A)
C Manzardo
(C)
J M Miró
(JM)
J García
(J)
I Paz
(I)
E Poveda
(E)
E Calderón
(E)
D Escudero
(D)
M Trigo
(M)
J Diz
(J)
M García-Campello
(M)
M Rodríguez-Iglesias
(M)
A Hernández-Betancor
(A)
A M Martín
(AM)
J M Ramos
(JM)
A Gimeno
(A)
F Gutiérrez
(F)
J C Rodríguez
(JC)
V Sánchez
(V)
C Gómez-Hernando
(C)
G Cilla
(G)
E Pérez-Trallero
(E)
J López-Aldeguer
(J)
L Fernández-Pereira
(L)
J Niubó
(J)
M Hernández
(M)
A M López-Lirola
(AM)
J L Gómez-Sirvent
(JL)
L Force
(L)
C Cifuentes
(C)
S Pérez
(S)
L Morano
(L)
C Raya
(C)
A González-Praetorius
(A)
J L Pérez
(JL)
M Peñaranda
(M)
S Hernáez-Crespo
(S)
J M Montejo
(JM)
L Roc
(L)
A Martínez-Sapiña
(A)
I Viciana
(I)
T Cabezas
(T)
A Lozano
(A)
J M Fernández
(JM)
I García-Bermejo
(I)
G Gaspar
(G)
R García
(R)
M Górgolas
(M)
C Vegas
(C)
J Blas
(J)
P Miralles
(P)
M Valeiro
(M)
T Aldamiz
(T)
N Margall
(N)
C Guardia
(C)
E do Pico
(E)
I Polo
(I)
A Aguinaga
(A)
C Ezpeleta
(C)
S Sauleda
(S)
M Pirón
(M)
R González
(R)
L Barea
(L)
A Jiménez
(A)
L Blanco
(L)
A Suárez
(A)
I Rodríguez-Avial
(I)
A Pérez-Rivilla
(A)
P Parra
(P)
M Fernández
(M)
M Fernández-Alonso
(M)
G Reina
(G)
A Treviño
(A)
S Requena
(S)
L Benítez-Gutiérrez
(L)
V Cuervas-Mons
(V)
C de Mendoza
(C)
P Barreiro
(P)
V Soriano
(V)
O Corral
(O)
F Gómez-Gallego
(F)
Déclaration de conflit d'intérêts
Conflict of interest statement: The author(s) declare that there is no conflict of interest.
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