Broadening phenotype of adenylosuccinate lyase deficiency: A novel clinical pattern resembling neuronal ceroid lipofuscinosis.

Children Drug- resistant epilepsy Neurodegenerative disorders Purine metabolism Retinopathy

Journal

Molecular genetics and metabolism reports
ISSN: 2214-4269
Titre abrégé: Mol Genet Metab Rep
Pays: United States
ID NLM: 101624422

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 20 05 2019
revised: 07 08 2019
accepted: 07 08 2019
entrez: 31 8 2019
pubmed: 31 8 2019
medline: 31 8 2019
Statut: epublish

Résumé

We describe a 7-year-old boy presenting with a developmental encephalopathy, severe epilepsy, retinopathy with salt and pepper fundus, and ultrastructural skin alterations resembling a neuronal ceroid lipofuscinosis. Whole exome-sequencing detected biallelic variants in the

Identifiants

pubmed: 31467849
doi: 10.1016/j.ymgmr.2019.100502
pii: S2214-4269(19)30081-3
pii: 100502
pmc: PMC6713842
doi:

Types de publication

Case Reports

Langues

eng

Pagination

100502

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Auteurs

Mario Mastrangelo (M)

Division of Child Neurology and Infantile Psychiatry, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Chiara Alfonsi (C)

Division of Child Neurology and Infantile Psychiatry, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Isabella Screpanti (I)

Department of Molecular Medicine, Sapienza University of Rome, Italy.

Laura Masuelli (L)

Department of Experimental Medicine, Sapienza University of Rome, Italy.

Barbara Tavazzi (B)

Institute of Biochemistry and Clinical Biochemistry Catholic University, Rome.
Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy.

Davide Mei (D)

Neuroscience and Neurogenetics Excellence Centre, Children's Hospital Anna Meyer, Florence, Italy.

Flavia Giannotti (F)

Division of Child Neurology and Infantile Psychiatry, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Renzo Guerrini (R)

Neuroscience and Neurogenetics Excellence Centre, Children's Hospital Anna Meyer, Florence, Italy.

Vincenzo Leuzzi (V)

Division of Child Neurology and Infantile Psychiatry, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Classifications MeSH