Association of Variants in IL6-Related Genes with Lung Cancer Risk in Moroccan Population.
Adult
Aged
Aged, 80 and over
Case-Control Studies
Cytokine Receptor gp130
/ genetics
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Interleukin-6
/ genetics
Lung Neoplasms
/ diagnosis
Male
Middle Aged
Morocco
Phenotype
Polymorphism, Single Nucleotide
Receptors, Interleukin-6
/ genetics
Risk Assessment
Risk Factors
Cytokines
Inflammation
Lung cancer
Moroccan population
Polymorphisms
Risk
Journal
Lung
ISSN: 1432-1750
Titre abrégé: Lung
Pays: United States
ID NLM: 7701875
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
15
04
2019
accepted:
08
08
2019
pubmed:
31
8
2019
medline:
1
5
2020
entrez:
31
8
2019
Statut:
ppublish
Résumé
Lung cancer is known to be a complex multifactorial disease, involving both genetic and environmental factors. The study of the different signaling pathways and the identification of the genes involved, will contribute to further understanding the pathogenesis of the disease, thus allowing the development of appropriate targeted treatments. Recently, the link between cancer and inflammation has become more evident and inflammation has been proposed as the seventh hallmark of cancer. Previous studies have suggested that key cytokines involved in inflammation may have an important role in the etiology of lung cancer. The aim of this study was to investigate whether common variants in inflammation-related genes: IL-6, IL6-R, and IL6-ST, influence lung cancer risk in Moroccan population. Single nucleotide polymorphisms (SNPs) in IL-6, IL6-R, and IL6-ST genes were assessed in 120 controls and 120 patients with confirmed lung cancer diagnosis. Genotyping analysis was performed with the TaqMan® allelic discrimination technology. The results were analyzed using SPSS 24.0 software. Among the studied SNPs, we found a significant association for the IL-6 (rs2069840) (OR = 1.63; 95% confidence interval 1.08-2.47; p = 0.01). No significant association was observed for the remaining SNPs of IL-6R (rs2228145) and IL-6ST (rs2228044) genes. Our results suggest the IL-6 (rs2069840) polymorphism may influence the occurrence of lung cancer in Moroccan patients.
Identifiants
pubmed: 31468132
doi: 10.1007/s00408-019-00261-0
pii: 10.1007/s00408-019-00261-0
doi:
Substances chimiques
IL6 protein, human
0
IL6R protein, human
0
IL6ST protein, human
0
Interleukin-6
0
Receptors, Interleukin-6
0
Cytokine Receptor gp130
133483-10-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
601-608Références
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