[Determinants of health-related quality of life in systemic lupus erythematosus: a monocentric, retrospective long-term observational study in Germany].
Determinanten gesundheitsbezogener Lebensqualität bei systemischem Lupus erythematodes: eine monozentrische, retrospektive Langzeitobservationsstudie in Deutschland.
Antimalarial agents
Fatigue
Glucocorticoids
Health-related quality of life
Mental component summary
Physical component summary
SF-36
Systemic lupus erythematosus
Journal
Zeitschrift fur Rheumatologie
ISSN: 1435-1250
Titre abrégé: Z Rheumatol
Pays: Germany
ID NLM: 0414162
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
pubmed:
31
8
2019
medline:
28
11
2019
entrez:
31
8
2019
Statut:
ppublish
Résumé
Improvement of health-related quality of life (HRQoL) is a prioritized treatment target in systemic lupus erythematosus (SLE). A retrospective chart review of patients with repeated HRQoL measurements from the outpatient department was conducted in order to better understand which factors drive HRQoL in established SLE. Of particular interest was the association between HRQoL and disease activity. The medical outcomes study short form 36 (SF-36), systemic lupus activity measure (SLAM) and routine clinical data of 169 patients (83% female, mean age 40.3 ± 13 years, disease duration 9.4 ± 7 years) over an average of 7.1 ± 4.2 years were available for analysis by linear mixed modelling. Factors associated with the physical component summary (PCS) and mental component summary (MCS) of the SF-36 were assessed. The proportion of HRQoL which could be explained by the variables was estimated by marginal R At baseline, SLE patients showed a reduced HRQoL in all subscales of the SF-36 including PCS and MCS with the exception of vitality. A higher PCS over time was significantly associated with concurrent parameters, such as intake of antimalarial drugs, no glucocorticoid use, less fatigue, lower disease activity as well as to the baseline parameters of younger age and higher PCS (mR The use of antimalarial drugs and no glucocorticoid intake as well as low current disease activity are modifiable factors associated with a better physical HRQoL. The mental component of HRQoL was poorly represented by conventional parameters and not associated with parameters of disease activity in the present study cohort.
Sections du résumé
BACKGROUND
BACKGROUND
Improvement of health-related quality of life (HRQoL) is a prioritized treatment target in systemic lupus erythematosus (SLE). A retrospective chart review of patients with repeated HRQoL measurements from the outpatient department was conducted in order to better understand which factors drive HRQoL in established SLE. Of particular interest was the association between HRQoL and disease activity.
METHODS
METHODS
The medical outcomes study short form 36 (SF-36), systemic lupus activity measure (SLAM) and routine clinical data of 169 patients (83% female, mean age 40.3 ± 13 years, disease duration 9.4 ± 7 years) over an average of 7.1 ± 4.2 years were available for analysis by linear mixed modelling. Factors associated with the physical component summary (PCS) and mental component summary (MCS) of the SF-36 were assessed. The proportion of HRQoL which could be explained by the variables was estimated by marginal R
RESULTS
RESULTS
At baseline, SLE patients showed a reduced HRQoL in all subscales of the SF-36 including PCS and MCS with the exception of vitality. A higher PCS over time was significantly associated with concurrent parameters, such as intake of antimalarial drugs, no glucocorticoid use, less fatigue, lower disease activity as well as to the baseline parameters of younger age and higher PCS (mR
CONCLUSION
CONCLUSIONS
The use of antimalarial drugs and no glucocorticoid intake as well as low current disease activity are modifiable factors associated with a better physical HRQoL. The mental component of HRQoL was poorly represented by conventional parameters and not associated with parameters of disease activity in the present study cohort.
Identifiants
pubmed: 31468165
doi: 10.1007/s00393-019-00691-4
pii: 10.1007/s00393-019-00691-4
doi:
Types de publication
Journal Article
Langues
ger
Sous-ensembles de citation
IM
Pagination
813-819Références
Lupus Sci Med. 2014 Jun 26;1(1):e000031
pubmed: 25396065
J Rheumatol. 2000 Jun;27(6):1414-20
pubmed: 10852263
RMD Open. 2019 Jun 11;5(2):e000916
pubmed: 31275608
Ann Rheum Dis. 2019 Jun;78(6):736-745
pubmed: 30926722
Lupus. 2000;9(5):322-7
pubmed: 10878722
Ann Rheum Dis. 2014 Jun;73(6):958-67
pubmed: 24739325
Arthritis Care Res (Hoboken). 2019 Jun;71(6):811-821
pubmed: 30055091
Lupus. 2004;13(12):924-6
pubmed: 15645747
Lupus. 2010 Dec;19(14):1606-13
pubmed: 20829309
J Rheumatol. 1997 Nov;24(11):2145-8
pubmed: 9375874
Arthritis Rheum. 1997 Jan;40(1):47-56
pubmed: 9008599
Expert Rev Clin Immunol. 2018 Nov;14(11):915-931
pubmed: 30266076
J Clin Epidemiol. 1998 Nov;51(11):903-12
pubmed: 9817107
Arthritis Rheum. 2004 Jun 15;51(3):465-74
pubmed: 15188335
Presse Med. 2014 Jun;43(6 Pt 2):e197-207
pubmed: 24791601