Ex vivo infection of human placental explants with Trypanosoma cruzi and Toxoplasma gondii: Differential activation of NF kappa B signaling pathways.
NF-κB signaling
Placenta
Toxoplasma gondii
Trypanosoma cruzi
Journal
Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
30
04
2019
revised:
24
07
2019
accepted:
20
08
2019
pubmed:
31
8
2019
medline:
18
12
2019
entrez:
31
8
2019
Statut:
ppublish
Résumé
Trypanosoma cruzi (T. cruzi) and Toxoplasma gondii (T. gondii) are the causative agents of Chagas disease and Toxoplasmosis. T. cruzi and T. gondii present, respectively, low and high congenital transmission rates and induce a distinctive cytokine/chemokine profile in ex vivo infected human placental explants (HPE). Since the innate immune response is regulated, at least partially, by NF-κB signaling pathways, our main objective was to determine the effect of ex vivo infection with both parasites on the activation of canonical and non-canonical NF-κB pathways and its relation to parasite infection. T. cruzi activates both, the canonical and non-canonical pathways of NF-κB, unlike T. gondii, which has no effect on the canonical pathway and inhibits the non-canonical pathway. The inhibition of both pathways of NF-κB increases the DNA load of T. cruzi and T. gondii in HPE. Therefore, the differential modulation of NF-κB signal transduction pathways by both parasites might explain, at least partially, the low and high congenital transmission rates of T. cruzi and T. gondii.
Identifiants
pubmed: 31469971
pii: S0001-706X(19)30595-9
doi: 10.1016/j.actatropica.2019.105153
pii:
doi:
Substances chimiques
NF-kappa B
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105153Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.