Anti-parasitic dinuclear thiolato-bridged arene ruthenium complexes alter the mitochondrial ultrastructure and membrane potential in Trypanosoma brucei bloodstream forms.
Animals
Dose-Response Relationship, Drug
Fluorescent Antibody Technique
Humans
Inhibitory Concentration 50
Membrane Potential, Mitochondrial
/ drug effects
Microscopy, Electron, Transmission
Mitochondria
/ drug effects
Ruthenium Compounds
/ chemistry
Time Factors
Trypanosoma brucei brucei
/ drug effects
Trypanosomiasis, African
/ blood
Journal
Experimental parasitology
ISSN: 1090-2449
Titre abrégé: Exp Parasitol
Pays: United States
ID NLM: 0370713
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
25
06
2019
revised:
20
08
2019
accepted:
25
08
2019
pubmed:
31
8
2019
medline:
8
10
2019
entrez:
31
8
2019
Statut:
ppublish
Résumé
Trypanosoma brucei causes human African trypanosomiasis and Nagana disease in cattle, imposing substantial medical and economic burden in sub-Saharan Africa. The current treatments have limitations, including the requirement for elaborated protocols, development of drug resistance, and they are prone to adverse side effects. In vitro screening of a library of 14 dinuclear-thiolato bridged arene ruthenium complexes, originally developed for treatment of cancer cells, resulted in the identification of 7 compounds with IC
Identifiants
pubmed: 31469986
pii: S0014-4894(19)30287-5
doi: 10.1016/j.exppara.2019.107753
pii:
doi:
Substances chimiques
Ruthenium Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107753Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.