Free-water imaging of the hippocampus is a sensitive marker of Alzheimer's disease.
Aged
Aged, 80 and over
Aging
Alzheimer Disease
/ diagnostic imaging
Biomarkers
Body Water
/ diagnostic imaging
Cognitive Dysfunction
/ diagnostic imaging
Female
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
/ standards
Male
Neuroimaging
/ standards
Positron-Emission Tomography
/ standards
Reproducibility of Results
Sensitivity and Specificity
Free-water imaging
Hippocampus
Mild cognitive impairment
Neurodegeneration
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
02
2019
revised:
30
06
2019
accepted:
14
08
2019
pubmed:
31
8
2019
medline:
22
9
2020
entrez:
31
8
2019
Statut:
ppublish
Résumé
Validating sensitive markers of hippocampal degeneration is fundamental for understanding neurodegenerative conditions such as Alzheimer's disease. In this paper, we test the hypothesis that free-water in the hippocampus will be more sensitive to early stages of cognitive decline than hippocampal volume, and that free-water in hippocampus will increase across distinct clinical stages of Alzheimer's disease. We examined two separate cohorts (N = 126; N = 112) of cognitively normal controls, early and late mild cognitive impairment (MCI), and Alzheimer's disease. Demographic, clinical, diffusion-weighted and T1-weighted imaging, and positron emission tomography (PET) imaging were assessed. Results indicated elevated hippocampal free-water in early MCI individuals compared to controls across both cohorts. In contrast, there was no difference in volume of these regions between controls and early MCI. ADNI free-water values in the hippocampus was associated with low CSF AB
Identifiants
pubmed: 31470214
pii: S2213-1582(19)30335-3
doi: 10.1016/j.nicl.2019.101985
pmc: PMC6722298
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101985Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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