Multilevel Impacts of Iron in the Brain: The Cross Talk between Neurophysiological Mechanisms, Cognition, and Social Behavior.
brain
cognition
iron
neurophysiology
social behavior
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
29 Aug 2019
29 Aug 2019
Historique:
received:
05
08
2019
revised:
26
08
2019
accepted:
27
08
2019
entrez:
1
9
2019
pubmed:
1
9
2019
medline:
1
9
2019
Statut:
epublish
Résumé
Iron is a critical element for most organisms, which plays a fundamental role in the great majority of physiological processes. So much so, that disruption of iron homeostasis has severe multi-organ impacts with the brain being particularly sensitive to such modifications. More specifically, disruption of iron homeostasis in the brain can affect neurophysiological mechanisms, cognition, and social behavior, which eventually contributes to the development of a diverse set of neuro-pathologies. This article starts by exploring the mechanisms of iron action in the brain and follows with a discussion on cognitive and behavioral implications of iron deficiency and overload and how these are framed by the social context. Subsequently, we scrutinize the implications of the disruption of iron homeostasis for the onset and progression of psychosocial disorders. Lastly, we discuss the links between biological, psychological, and social dimensions and outline potential avenues of research. The study of these interactions could ultimately contribute to a broader understanding of how individuals think and act under physiological and pathophysiological conditions.
Identifiants
pubmed: 31470556
pii: ph12030126
doi: 10.3390/ph12030126
pmc: PMC6789770
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : IF/01495/2015
Organisme : EOS - The Excellence of Science
ID : MODEL-IDI 30826052
Organisme : Fundação para a Ciência e a Tecnologia
ID : 03/SAICT/2015
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/IVC-ESCT/0073/2014
Organisme : Fundação para a Ciência e a Tecnologia
ID : UID/ECO/00124/2013
Organisme : Fundação para a Ciência e a Tecnologia
ID : UID/ECO/00124/2019
Organisme : Social Sciences DataLab
ID : LISBOA-01-0145-FEDER-022209
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