Platelet-Activating Factor (PAF) in Allergic Rhinitis: Clinical and Therapeutic Implications.
PAF antagonist
allergic rhinitis
anaphylaxis
asthma
epinastine
ketotifen
nasal congestion
platelet-activating factor
rupatadine
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
29 Aug 2019
29 Aug 2019
Historique:
received:
06
08
2019
revised:
26
08
2019
accepted:
27
08
2019
entrez:
1
9
2019
pubmed:
1
9
2019
medline:
1
9
2019
Statut:
epublish
Résumé
Platelet-activating factor (PAF) is a lipid mediator involved in several allergic reactions. It is released from multiple cells of the immune system, such as eosinophils, neutrophils, and mast cells, and also exerts its effect on most of them upon specific binding to its receptor, becoming a pleiotropic mediator. PAF is considered a potential relevant mediator in allergic rhinitis, with a key role in nasal congestion and rhinorrhoea due to its effect on vascular permeability. Interestingly, despite its potential relevance as a therapeutic target, no specific PAF inhibitors have been studied in humans. However, rupatadine, a second-generation antihistamine with dual antihistamine and anti-PAF effects has shown promising results by both blocking nasal symptoms and inhibiting mast cell activation induced by PAF, in comparison to antihistamine receptor drugs. In conclusion, the inhibition of PAF may be an interesting approach in the treatment of allergic rhinitis as part of a global strategy directed at blocking as many relevant inflammatory mediators as possible.
Identifiants
pubmed: 31470575
pii: jcm8091338
doi: 10.3390/jcm8091338
pmc: PMC6780525
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Allergy. 2008 Apr;63 Suppl 87:5-28
pubmed: 18339040
Thorax. 1993 Jun;48(6):594-8
pubmed: 8346486
Postgrad Med. 2009 Jan;121(1):122-31
pubmed: 19179820
Drugs. 1998 Jul;56(1):91-114
pubmed: 9664202
Allergy. 1991 Aug;46(6):466-71
pubmed: 1720286
Br J Pharmacol. 1993 Sep;110(1):113-8
pubmed: 8220870
J Allergy Clin Immunol. 1994 Feb;93(2):526-33
pubmed: 8120279
Cochrane Database Syst Rev. 2004;(1):CD001384
pubmed: 14973969
Clin Rev Allergy Immunol. 2006 Feb;30(1):3-11
pubmed: 16461989
J Fam Pract. 2012 Feb;61(2 Suppl):S16-22
pubmed: 22312620
J Allergy Clin Immunol. 2009 Aug;124(2):307-14, 314.e1-2
pubmed: 19409603
J Allergy Clin Immunol. 2009 Oct;124(4):786-92.e4
pubmed: 19767073
Immunol Today. 1987;8(11):345-51
pubmed: 25291060
J Biol Chem. 2014 May 30;289(22):15566-76
pubmed: 24742674
J Allergy Clin Immunol. 1990 Dec;86(6 Pt 1):839-50
pubmed: 2175758
J Clin Invest. 1999 Apr;103(7):989-97
pubmed: 10194471
Clin Exp Allergy. 2009 May;39(5):620-2
pubmed: 19400907
Int J Immunopathol Pharmacol. 2015 Dec;28(4):584-9
pubmed: 26486136
J Physiol Biochem. 2004 Jun;60(2):101-11
pubmed: 15457928
Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):523-7
pubmed: 10934081
Clin Exp Allergy. 2005 Apr;35(4):456-60
pubmed: 15836753
Prostaglandins Leukot Essent Fatty Acids. 1998 Feb;58(2):99-104
pubmed: 9578146
Allergol Int. 2011 Mar;60(1):69-77
pubmed: 21173568
J Immunol. 1985 Sep;135(3):2033-9
pubmed: 3160784
J Allergy Clin Immunol. 1991 Mar;87(3):667-73
pubmed: 2005318
Pulm Pharmacol Ther. 2000;13(5):195-223
pubmed: 11001865
Atherosclerosis. 2000 Jun;150(2):413-9
pubmed: 10856534
Eur J Pharmacol. 1987 Dec 1;144(2):133-9
pubmed: 2963750
J Allergy Clin Immunol. 2013 Jan;131(1):144-9
pubmed: 23040367
Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):111-8
pubmed: 2571942
Sci Transl Med. 2019 Jul 10;11(500):null
pubmed: 31292264
J Clin Invest. 2003 Dec;112(11):1666-77
pubmed: 14660743
Expert Opin Drug Saf. 2016 Oct;15(10):1439-48
pubmed: 27500993
Nature. 1974 Jun 7;249(457):581-2
pubmed: 4275800
Lancet. 1986 Jul 26;2(8500):189-92
pubmed: 2873440
Am J Rhinol Allergy. 2013 Mar-Apr;27(2):e48-52
pubmed: 23562190
Arzneimittelforschung. 1994 Mar;44(3):327-9
pubmed: 7910745
J Am Acad Dermatol. 2001 Sep;45(3):387-91
pubmed: 11511835
J R Coll Physicians Edinb. 2014;44(1):50-4
pubmed: 24995449
Allergy. 2015 Jan;70 Suppl 100:1-24
pubmed: 25491409
J Immunol. 2000 Mar 15;164(6):3360-7
pubmed: 10706731
Recent Pat Inflamm Allergy Drug Discov. 2008 Jan;2(1):72-6
pubmed: 19075994
J Exp Med. 1998 Jun 1;187(11):1779-88
pubmed: 9607919
J Allergy Clin Immunol. 2014 May;133(5):1270-7
pubmed: 24766875
N Engl J Med. 2008 Jan 3;358(1):28-35
pubmed: 18172172
J Allergy Clin Immunol. 1994 Jul;94(1):109-19
pubmed: 8027488
Immunopharmacol Immunotoxicol. 1992;14(1-2):207-18
pubmed: 1350791
Ann Allergy Asthma Immunol. 2013 Dec;111(6):542-7
pubmed: 24267366
J Investig Allergol Clin Immunol. 2017;27(3):161-168
pubmed: 27758758
Int Arch Allergy Immunol. 2004 Jun;134 Suppl 1:37-43
pubmed: 15166482
Blood. 2012 Mar 15;119(11):2533-44
pubmed: 22138510
J Allergy Clin Immunol. 2010 Sep;126(3):466-76
pubmed: 20816182
J Pharmacol Exp Ther. 1997 Jan;280(1):114-21
pubmed: 8996188
Prostaglandins Leukot Essent Fatty Acids. 1997 May;56(5):373-7
pubmed: 9175174
Clin Exp Allergy. 1995 Dec;25(12):1159-62
pubmed: 8821294
Biochem Biophys Res Commun. 2000 May 19;271(3):812-7
pubmed: 10814544
J Immunol Methods. 1993 Dec 3;166(2):251-61
pubmed: 8288878
J Allergy Clin Immunol. 2014 Apr;133(4):1218-20
pubmed: 24332861
J Clin Invest. 2011 Apr;121(4):1484-96
pubmed: 21436586
Allergy Asthma Clin Immunol. 2014 Apr 28;10(1):20
pubmed: 24808915
Fundam Clin Pharmacol. 1990;4(1):1-9
pubmed: 2111270
Clin Transl Allergy. 2019 Jul 17;9:33
pubmed: 31346408
J Allergy Clin Immunol. 2010 May;125(5):1137-1145.e6
pubmed: 20392487
Biochem J. 1993 Jun 15;292 ( Pt 3):617-29
pubmed: 8391253
Allergol Int. 2017 Apr;66(2):163-189
pubmed: 28196638
Cardiovasc Drugs Ther. 2009 Feb;23(1):73-83
pubmed: 18949548
Eur J Clin Pharmacol. 1992;42(3):295-9
pubmed: 1577048
Allergy Asthma Clin Immunol. 2013 Nov 01;9(1):43
pubmed: 24499312
J Pharmacol Exp Ther. 1998 Jan;284(1):83-8
pubmed: 9435164
J Immunol. 1980 Feb;124(2):676-84
pubmed: 7356708
Lipids. 1991 Dec;26(12):1172-4
pubmed: 1819703
J Allergy Clin Immunol. 2004 Sep;114(3):465-74; quiz 475
pubmed: 15356542
Drugs. 1990 Sep;40(3):412-48
pubmed: 2226222
Rheum Dis Clin North Am. 2016 Feb;42(1):15-31, vii
pubmed: 26611548
Eur J Pharmacol. 1992 Jun 5;216(2):141-7
pubmed: 1397002
Jpn J Pharmacol. 1990 Oct;54(2):217-26
pubmed: 2077186
Int Arch Allergy Immunol. 2012;158(1):18-26
pubmed: 22212397