Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration.
dentinogenesis
proteomics
pulp capping materials
wound healing
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
29 08 2019
29 08 2019
Historique:
received:
03
08
2019
revised:
22
08
2019
accepted:
28
08
2019
entrez:
1
9
2019
pubmed:
1
9
2019
medline:
27
5
2020
Statut:
epublish
Résumé
Dentin consists of inorganic hard tissue and organic dentin matrix components (DMCs). Various kinds of bioactive molecules are included in DMCs and some of them can be released after digestion by endogenous matrix metalloproteinases (MMPs) in the caries region. Digested DMCs induced by MMP20 have been reported to promote pulpal wound healing processes, but the released critical molecules responsible for this phenomenon are unclear. Here, we identified protein S100-A7 as a critical molecule for pulpal healing in digested DMCs by comprehensive proteomic approaches and following pulp capping experiments in rat molars. In addition, immunohistochemical results indicated the specific distribution of S100-A7 and receptor for advanced glycation end-products (RAGE) as receptor for S100-A7 in the early stage of the pulpal healing process, and following accumulation of CD146-positive stem cells in wounded pulp. Our findings indicate that protein S100-A7 released from dentin by MMP20 might play a key role in dentin pulp regeneration.
Identifiants
pubmed: 31470634
pii: cells8091002
doi: 10.3390/cells8091002
pmc: PMC6769619
pii:
doi:
Substances chimiques
S100 Calcium Binding Protein A7
0
S100A7 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Matrix Biol. 2009 May;28(4):221-9
pubmed: 19348940
Int J Cancer. 1995 Jan 17;60(2):216-20
pubmed: 7829219
Matrix Biol. 2015 May-Jul;44-46:113-21
pubmed: 25770908
Arch Oral Biol. 2012 Feb;57(2):109-21
pubmed: 21855856
Oncogene. 2004 Jan 29;23(4):964-72
pubmed: 14661054
Infect Immun. 2004 Jul;72(7):4102-8
pubmed: 15213155
J Immunol. 2008 Jul 15;181(2):1499-506
pubmed: 18606705
J Dent Res. 2016 Aug;95(9):1034-41
pubmed: 27126446
Exp Cell Res. 2008 Aug 1;314(13):2501-14
pubmed: 18602101
J Leukoc Biol. 2007 Jan;81(1):28-37
pubmed: 16943388
J Endod. 2010 Dec;36(12):1956-62
pubmed: 21092812
J Dent Res. 2004 Aug;83(8):590-5
pubmed: 15271965
Exp Cell Res. 2012 Nov 1;318(18):2397-406
pubmed: 22819733
J Endod. 2000 Sep;26(9):525-8
pubmed: 11199794
J Dent Res. 2006 Jan;85(1):22-32
pubmed: 16373676
Curr Mol Med. 2013 Jan;13(1):24-57
pubmed: 22834835
J Dent Res. 2014 Jul;93(7):671-7
pubmed: 24799420
Cell Tissue Res. 2007 Mar;327(3):511-9
pubmed: 17043795
Arch Oral Biol. 1984;29(12):1049-50
pubmed: 6398690
Caries Res. 2011;45(5):429-34
pubmed: 21860240
J Biol Chem. 2012 Aug 31;287(36):30426-35
pubmed: 22798071
Nat Med. 2009 Jul;15(7):757-65
pubmed: 19584867
Scand J Gastroenterol. 2004 Nov;39(11):1095-104
pubmed: 15545168
PLoS One. 2015 Mar 26;10(3):e0121938
pubmed: 25812134
PLoS One. 2015 May 07;10(5):e0125807
pubmed: 25951178
Bone. 2009 Oct;45(4):693-703
pubmed: 19555781
Ann N Y Acad Sci. 1990;593:91-7
pubmed: 2197964
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Eur J Oral Sci. 2012 Aug;120(4):259-68
pubmed: 22813215
Oper Dent. 2010 Jan-Feb;35(1):20-8
pubmed: 20166407
J Dent Res. 2016 Oct;95(11):1274-81
pubmed: 27384335
Dent J (Basel). 2016 Mar 25;4(2):null
pubmed: 29563450
Clin Oral Investig. 2018 Sep;22(7):2559-2566
pubmed: 29396644
J Biol Chem. 2007 Jan 12;282(2):1193-204
pubmed: 17052984
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13625-30
pubmed: 11087820
J Endod. 2014 Dec;40(12):1961-6
pubmed: 25305236
J Biol Chem. 2015 Jul 31;290(31):18991-8
pubmed: 26055713
Appl Environ Microbiol. 2014 Jul;80(13):3804-10
pubmed: 24747900
Int Endod J. 2013 Dec;46(12):1153-63
pubmed: 23600680
Cell Tissue Res. 2014 Apr;356(1):171-82
pubmed: 24562313
J Biol Chem. 2006 Dec 15;281(50):38235-43
pubmed: 17046814
J Biol Chem. 2002 Jun 14;277(24):21352-60
pubmed: 11929865
J Dent Res. 2010 Apr;89(4):355-9
pubmed: 20200415
Biochem Biophys Res Commun. 2014 Aug 8;450(4):1547-52
pubmed: 25019990
J Tissue Eng Regen Med. 2008 Dec;2(8):491-8
pubmed: 18956412
J Immunol. 2003 Jul 1;171(1):398-406
pubmed: 12817023
Mucosal Immunol. 2008 May;1(3):239-43
pubmed: 19079183
J Invest Dermatol. 2009 Mar;129(3):641-9
pubmed: 18754038
Sci Rep. 2018 Jul 16;8(1):10690
pubmed: 30013085
J Dent. 2007 Aug;35(8):636-42
pubmed: 17566626
Dent Mater J. 2013;32(6):976-85
pubmed: 24240903
Adv Drug Deliv Rev. 2002 Dec 7;54(12):1615-25
pubmed: 12453678
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
J Invest Dermatol. 2002 Jul;119(1):14-21
pubmed: 12164918
Am J Pathol. 2009 Aug;175(2):533-46
pubmed: 19590036
Sci Rep. 2017 Jun 12;7(1):3315
pubmed: 28607360
Eur J Oral Sci. 2013 Apr;121(2):76-85
pubmed: 23489896
J Biochem. 2013 Jan;153(1):43-50
pubmed: 23038674