Exosomal miRNAs in Lung Diseases: From Biologic Function to Therapeutic Targets.
acute lung injury/acute respiratory distress syndrome
asthma
chronic obstructive pulmonary disease
diagnostic biomarkers
exosomes
idiopathic pulmonary fibrosis
lung diseases
microRNAs
therapeutics
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
29 Aug 2019
29 Aug 2019
Historique:
received:
26
07
2019
revised:
26
08
2019
accepted:
27
08
2019
entrez:
1
9
2019
pubmed:
1
9
2019
medline:
1
9
2019
Statut:
epublish
Résumé
Increasing evidence suggests the potential role of extracellular vesicles (EVs) in many lung diseases. According to their subcellular origin, secretion mechanism, and size, EVs are currently classified into three subpopulations: exosomes, microvesicles, and apoptotic bodies. Exosomes are released in most biofluids, including airway fluids, and play a key role in intercellular communication via the delivery of their cargo (e.g., microRNAs (miRNAs)) to target cell. In a physiological context, lung exosomes present protective effects against stress signals which allow them to participate in the maintenance of lung homeostasis. The presence of air pollution alters the composition of lung exosomes (dysregulation of exosomal miRNAs) and their homeostatic property. Indeed, besides their potential as diagnostic biomarkers for lung diseases, lung exosomes are functional units capable of dysregulating numerous pathophysiological processes (including inflammation or fibrosis), resulting in the promotion of lung disease progression. Here, we review recent studies on the known and potential role of lung exosomes/exosomal miRNAs, in the maintaining of lung homeostasis on one hand, and in promoting lung disease progression on the other. We will also discuss using exosomes as prognostic/diagnostic biomarkers as well as therapeutic tools for lung diseases.
Identifiants
pubmed: 31470655
pii: jcm8091345
doi: 10.3390/jcm8091345
pmc: PMC6781233
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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