In-house Implementation of Tumor Mutational Burden Testing to Predict Durable Clinical Benefit in Non-small Cell Lung Cancer and Melanoma Patients.

Tumor mutational burden (TMB) has emerged as an important potential biomarker for prediction of response to immune-checkpoint inhibitors (ICIs), notably in non-small cell lung cancer (NSCLC). However, its in-house assessment in routine clinical practice is currently challenging and validation is urgently needed. We have analyzed sixty NSCLC and thirty-six melanoma patients with ICI treatment, using the FoundationOne test (FO) in addition to in-house testing using the Oncomine TML (OTML) panel and evaluated the durable clinical benefit (DCB), defined by >6 months without progressive disease. Comparison of TMB values obtained by both tests demonstrated a high correlation in NSCLC (

Déclaration de conflit d'intérêts

Simon Heeke has received honoraria from Qiagen. Michel Poudenx has received honoraria from Roche, BMS, MSD and Pfizer and has been an investigator for Novartis and MSD. Thierry Passeron has received honoraria from Novartis, Roche, BMS, SANOFI and has been an investigator for Novartis, Roche, BMS, MSD, AMGEN, Pierre Fabre and SANOFI. Albrecht Stenzinger has received advisory board honoraria from AstraZeneca, Bayer, BMS, Illumina, Novartis, Seattle Genomics, Takeda, ThermoFisher, speaker’s honoraria from AstraZeneca, Bayer, BMS, Illumina, MSD, Novartis, Roche, Seattle Genomics, Takeda, ThermoFisher as well as research funding from Chugai and BMS. Marius Ilié has received honoraria from Roche, Merck & co, AstraZeneca, BMS and Boehringer Ingelheim. Paul Hofman has received honoraria from Roche, AstraZeneca, BMS, Novartis, Merck, MSD, Qiagen, Thermo Fisher and Biocartis. All other authors have no conflict of interest to declare.