Astrocytes: From the Physiology to the Disease.
Alzheimer's disease
Astrocytes
Huntington's disease
Parkinson's disease
amyotrophic
lateral sclerosis
neurodegenerative diseases
neuroinflammation.
Journal
Current Alzheimer research
ISSN: 1875-5828
Titre abrégé: Curr Alzheimer Res
Pays: United Arab Emirates
ID NLM: 101208441
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
01
2019
revised:
12
04
2019
accepted:
17
05
2019
pubmed:
1
9
2019
medline:
7
10
2020
entrez:
1
9
2019
Statut:
ppublish
Résumé
Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and exocytosis, and synaptic transmission. Many of these functions are intrinsically related to neurodegeneration, allowing refocusing on the role of astrocytes in physiological and neurodegenerative states. Indeed, emerging evidence in the field indicates that abnormalities in the astrocytic function are involved in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer's Disease (AD), Parkinson's Disease (PD), Huntington's Disease (HD) and Amyotrophic Lateral Sclerosis (ALS). In the present review, we highlight the physiological role of astrocytes in the CNS, including their communication with other cells in the brain. Furthermore, we discuss exciting findings and novel experimental approaches that elucidate the role of astrocytes in multiple neurological disorders.
Identifiants
pubmed: 31470787
pii: CAR-EPUB-100542
doi: 10.2174/1567205016666190830110152
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
675-698Informations de copyright
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