A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila.
Animals
Appetitive Behavior
/ physiology
Behavior, Animal
Dopamine
/ metabolism
Dopaminergic Neurons
/ metabolism
Drosophila Proteins
/ metabolism
Drosophila melanogaster
Food
Hunger
Motivation
Mushroom Bodies
/ cytology
Neural Pathways
/ physiology
Neurons
/ metabolism
Octopamine
/ metabolism
Odorants
Receptors, Dopamine D1
/ metabolism
Reward
Smell
DopR2
Drosophila melanogaster
dopamine
foraging
goal-directed behavior
learning
mushroom body
octopamine
olfactory system
persistence
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
06 11 2019
06 11 2019
Historique:
received:
15
04
2019
revised:
09
06
2019
accepted:
22
07
2019
pubmed:
1
9
2019
medline:
31
3
2020
entrez:
1
9
2019
Statut:
ppublish
Résumé
In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive.
Identifiants
pubmed: 31471123
pii: S0896-6273(19)30654-3
doi: 10.1016/j.neuron.2019.07.028
pmc: PMC6839618
pii:
doi:
Substances chimiques
Dop1R2 protein, Drosophila
0
Drosophila Proteins
0
Receptors, Dopamine D1
0
Octopamine
14O50WS8JD
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
544-558.e6Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203261/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105188491
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : RF1 MH120679
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.
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