Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1.

Adult Bacterial Infections / etiology Hematopoietic Stem Cell Transplantation / adverse effects Humans Infections / etiology Leukemia, Myeloid, Acute / complications Myeloablative Agonists / adverse effects Remission Induction Time Factors Transplantation Conditioning / adverse effects Transplantation, Homologous / adverse effects Treatment Outcome

Journal

Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425

Informations de publication

Date de publication:
10 09 2019
Historique:
received: 29 03 2019
accepted: 15 06 2019
entrez: 1 9 2019
pubmed: 1 9 2019
medline: 4 9 2020
Statut: ppublish

Résumé

Presumably, reduced-intensity/nonmyeloablative conditioning (RIC/NMA) for allogeneic hematopoietic cell transplantation (alloHCT) results in reduced infections compared with myeloablative conditioning (MAC) regimens; however, published evidence is limited. In this Center for International Blood and Marrow Transplant Research study, 1755 patients (aged ≥40 years) with acute myeloid leukemia in first complete remission were evaluated for infections occurring within 100 days after T-cell replete alloHCT. Patients receiving RIC/NMA (n = 777) compared with those receiving MAC (n = 978) were older and underwent transplantation more recently; however, the groups were similar regarding Karnofsky performance score, HCT-comorbidity index, and cytogenetic risk. One or more infections occurred in 1045 (59.5%) patients (MAC, 595 [61%]; RIC/NMA, 450 [58%];

Identifiants

DOI: 10.1182/bloodadvances.2019000226 PMID: 31471322 PMC: PMC6737406
pubmed: 31471322
pii: bloodadvances.2019000226
doi: 10.1182/bloodadvances.2019000226
pmc: PMC6737406
doi:

Substances chimiques

Myeloablative Agonists 0

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2525-2536

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL069294
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA076518
Pays : United States

Informations de copyright

© 2019 by The American Society of Hematology.

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Auteurs

Celalettin Ustun (C)

Division of Hematology/Oncology/Cell Therapy, Rush University, Chicago, IL.
ORCID: 0000-0001-6896-6213

Soyoung Kim (S)

Center for International Blood and Marrow Transplant Research, Department of Medicine, and.
Division of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI.
ORCID: 0000-0003-1404-0575

Min Chen (M)

Center for International Blood and Marrow Transplant Research, Department of Medicine, and.

Amer M Beitinjaneh (AM)

Department of Hematology, University of Miami, Miami, FL.

Valerie I Brown (VI)

Division of Pediatric Oncology/Hematology, Department of Pediatrics, Penn State Hershey Children's Hospital and College of Medicine, Hershey, PA.

Parastoo B Dahi (PB)

Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.

Andrew Daly (A)

Tom Baker Cancer Center, Calgary, AB, Canada.

Miguel Angel Diaz (MA)

Department of Hematology/Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.

Cesar O Freytes (CO)

Texas Transplant Institute, San Antonio, TX.
ORCID: 0000-0003-2880-6797

Siddhartha Ganguly (S)

Division of Hematological Malignancy and Cellular Therapeutics, University of Kansas Health System, Kansas City, KS.

Shahrukh Hashmi (S)

Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
ORCID: 0000-0002-8914-7927

Gerhard C Hildebrandt (GC)

Markey Cancer Center, University of Kentucky, Lexington, KY.
ORCID: 0000-0003-0478-3340

Hillard M Lazarus (HM)

Stem Cell Transplant Program, Division of Hematology and Oncology, Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH.
ORCID: 0000-0002-1159-5607

Taiga Nishihori (T)

Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
ORCID: 0000-0002-2621-7924

Richard F Olsson (RF)

Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0001-5970-2128

Kristin M Page (KM)

Division of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC.

Genovefa Papanicolaou (G)

Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, New York, NY.

Ayman Saad (A)

Division of Hematology, The Ohio State University, Columbus, OH.
ORCID: 0000-0003-0003-0130

Sachiko Seo (S)

Department of Haematology and Oncology, Dokkyo Medical University, Tochigi, Japan.

Basem M William (BM)

Division of Hematology, The Ohio State University, Columbus, OH.

John R Wingard (JR)

Division of Hematology & Oncology, Department of Medicine, University of Florida, Gainesville, FL.

Baldeep Wirk (B)

Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, WA.

Jean A Yared (JA)

Blood & Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD.
ORCID: 0000-0002-5346-6299

Miguel-Angel Perales (MA)

Adult Bone Marrow Transplant Services, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Jeffery J Auletta (JJ)

Blood and Marrow Transplant Program and.
Host Defense Program, Division of Hematology, Oncology, and Blood Marrow & Transplant, and.
Division of Infectious Diseases, Nationwide Children's Hospital, Columbus, OH.

Krishna V Komanduri (KV)

Department of Hematology, University of Miami, Miami, FL.
ORCID: 0000-0003-3715-5236

Caroline A Lindemans (CA)

Pediatric Blood and Marrow Transplantation Program, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands; and.

Marcie L Riches (ML)

Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
ORCID: 0000-0003-0257-0990

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Increased overall and bacterial infections...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Increased overall and bacterial infections...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Increased overall and bacterial infections...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Increased overall and bacterial infections...
questionsmedicales.fr › Infection › Increased overall and bacterial infections...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Increased overall and bacterial infections...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Agonistes myélo-ablatifs › Increased overall and bacterial infections...
questionsmedicales.fr › Thérapeutique › Induction de rémission › Increased overall and bacterial infections...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Increased overall and bacterial infections...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Conditionnement pour greffe › Increased overall and bacterial infections...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation homologue › Increased overall and bacterial infections...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Increased overall and bacterial infections...