Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits.
HIV-1
Wnt
microglia
pain
spinal cord
synaptic degeneration
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
16 10 2019
16 10 2019
Historique:
received:
05
11
2018
revised:
23
08
2019
accepted:
26
08
2019
pubmed:
1
9
2019
medline:
4
7
2020
entrez:
1
9
2019
Statut:
ppublish
Résumé
HIV-1 infection of the nervous system causes various neurological diseases, and synaptic degeneration is likely a critical step in the neuropathogenesis. Our prior studies revealed a significant decrease of synaptic protein, specifically in the spinal dorsal horn of patients with HIV-1 in whom pain developed, suggesting a potential contribution of synaptic degeneration to the pathogenesis of HIV-associated pain. However, the mechanism by which HIV-1 causes the spinal synaptic degeneration is unclear. Here, we identified a critical role of microglia in the synaptic degeneration. In primary cortical cultures (day
Identifiants
pubmed: 31471472
pii: JNEUROSCI.2851-18.2019
doi: 10.1523/JNEUROSCI.2851-18.2019
pmc: PMC6794928
doi:
Substances chimiques
CX3C Chemokine Receptor 1
0
Chemokine CX3CL1
0
Cx3cr1 protein, mouse
0
HIV Envelope Protein gp120
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8408-8421Subventions
Organisme : NIDA NIH HHS
ID : R01 DA036165
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA050530
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS079166
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095747
Pays : United States
Informations de copyright
Copyright © 2019 the authors.
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