Assessment of interstitial lung disease among black rheumatoid arthritis patients.
Black or African American
/ statistics & numerical data
Aged
Arthritis, Rheumatoid
/ complications
Cardiovascular Diseases
/ complications
Comorbidity
Cross-Sectional Studies
Female
Gastroesophageal Reflux
/ complications
Humans
Lung Diseases, Interstitial
/ epidemiology
Male
Middle Aged
New York
/ epidemiology
Prevalence
Retrospective Studies
Risk Factors
Associated autoimmune disease
Asthma
Chronic obstructive pulmonary disease
Erosive disease
Extra-articular manifestations
Multidisciplinary meetings
Non-specific interstitial pneumonia
Pulmonary function test
Rheumatoid arthritis
Rheumatoid arthritis–related interstitial lung disease
Seropositive rheumatoid arthritis
Therapeutic patterns
Usual interstitial pneumonia
Journal
Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
25
06
2019
accepted:
20
08
2019
revised:
01
08
2019
pubmed:
1
9
2019
medline:
9
4
2020
entrez:
1
9
2019
Statut:
ppublish
Résumé
Conflicting reports exist regarding the racial and the gender distribution of rheumatoid arthritis-related interstitial lung disease (RA-ILD). In a major population study of predominately Whites, RA-ILD was reported mainly among smoker middle-aged men. However, recent data suggest that the disease is that of elderly women. Our study aimed to assess the prevalence and identify the gender differences and clinical characteristics of RA-ILD in a predominantly Black population. Cross-sectional analysis of data obtained from the records of 1142 patients with RA diagnosis by ICD codes of which 503 cases met the inclusion criteria for the study. Eighty-six patients had chronic respiratory symptoms of cough and dyspnea and were further assessed by our multidisciplinary group of investigators. Thirty-two subjects with an established diagnosis of rheumatoid arthritis met the diagnostic criteria for interstitial lung disease. Of the 32 patients with RA-ILD, mean age was 62.6 ± 2.2 (± SEM), 93.7% were females, and 89% Blacks with a BMI = 29.2 (Kg/m Our study indicates RA-ILD among Blacks is predominantly a disease of elderly females with higher rates of GERD and CVD risk factors. Further studies are needed to identify the pathogenetic differences accounting for the gender distribution of RA-ILD among Black and White populations.Key Points• First study to assess ILD among predominantly Black RA patients.• The prevalence of RA-associated ILD was 6.36%, affecting mostly women in their sixth decade with seropositive disease.• COPD was the most common airway disease among non-RA-ILD Black population.• GERD was found in approximately one-third of patients with RA-associated ILD versus one-fifth of those RA patients without any lung disease.
Sections du résumé
BACKGROUND
BACKGROUND
Conflicting reports exist regarding the racial and the gender distribution of rheumatoid arthritis-related interstitial lung disease (RA-ILD). In a major population study of predominately Whites, RA-ILD was reported mainly among smoker middle-aged men. However, recent data suggest that the disease is that of elderly women. Our study aimed to assess the prevalence and identify the gender differences and clinical characteristics of RA-ILD in a predominantly Black population.
METHODS
METHODS
Cross-sectional analysis of data obtained from the records of 1142 patients with RA diagnosis by ICD codes of which 503 cases met the inclusion criteria for the study. Eighty-six patients had chronic respiratory symptoms of cough and dyspnea and were further assessed by our multidisciplinary group of investigators. Thirty-two subjects with an established diagnosis of rheumatoid arthritis met the diagnostic criteria for interstitial lung disease.
RESULTS
RESULTS
Of the 32 patients with RA-ILD, mean age was 62.6 ± 2.2 (± SEM), 93.7% were females, and 89% Blacks with a BMI = 29.2 (Kg/m
CONCLUSION
CONCLUSIONS
Our study indicates RA-ILD among Blacks is predominantly a disease of elderly females with higher rates of GERD and CVD risk factors. Further studies are needed to identify the pathogenetic differences accounting for the gender distribution of RA-ILD among Black and White populations.Key Points• First study to assess ILD among predominantly Black RA patients.• The prevalence of RA-associated ILD was 6.36%, affecting mostly women in their sixth decade with seropositive disease.• COPD was the most common airway disease among non-RA-ILD Black population.• GERD was found in approximately one-third of patients with RA-associated ILD versus one-fifth of those RA patients without any lung disease.
Identifiants
pubmed: 31471819
doi: 10.1007/s10067-019-04760-6
pii: 10.1007/s10067-019-04760-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3413-3424Subventions
Organisme : NIMHD NIH HHS
ID : P20 MD006875
Pays : United States
Organisme : NIH HHS
ID : S21MD012474.
Pays : United States
Références
Ann Rheum Dis. 2014 Jan;73(1):62-8
pubmed: 24095940
Reumatismo. 2018 Dec 20;70(4):212-224
pubmed: 30570239
Eur Respir J. 2011 Jun;37(6):1411-7
pubmed: 20884744
Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Dec 18;50(6):986-990
pubmed: 30562769
Radiology. 2014 Feb;270(2):583-8
pubmed: 24126367
Thorax. 2003 Feb;58(2):143-8
pubmed: 12554898
Semin Arthritis Rheum. 2018 Apr;47(5):639-648
pubmed: 29037522
Chest. 2018 Jun;153(6):1416-1423
pubmed: 29608882
Lancet Respir Med. 2018 Feb;6(2):138-153
pubmed: 29154106
Rheumatology (Oxford). 2014 Sep;53(9):1676-82
pubmed: 24758887
J Hypertens. 2007 May;25(5):965-70
pubmed: 17414659
J Rheumatol. 2019 Apr;46(4):360-369
pubmed: 30442831
Ann Rheum Dis. 2017 Oct;76(10):1700-1706
pubmed: 28611082
Ann Rheum Dis. 2013 Sep 1;72(9):1517-23
pubmed: 23065733
Rheumatology (Oxford). 2010 Aug;49(8):1483-9
pubmed: 20223814
Int J Rheumatol. 2016;2016:4609486
pubmed: 27630714
Clin Rheumatol. 2017 Apr;36(4):817-823
pubmed: 28191607
Proc Am Thorac Soc. 2006 Jun;3(4):315-21
pubmed: 16738195
Mayo Clin Proc. 2019 Feb;94(2):309-325
pubmed: 30558827
Respir Med. 2017 Feb;123:56-62
pubmed: 28137497
Am J Med. 2013 Dec;126(12):1089-98
pubmed: 24262723
Ann Rheum Dis. 2008 Mar;67(3):375-9
pubmed: 17644537
Lancet. 2010 Sep 25;376(9746):1094-108
pubmed: 20870100
Br Med J. 1948 Nov 6;2(4583):816-20
pubmed: 18890308
Allergy Asthma Proc. 2015 Sep-Oct;36(5):99-103
pubmed: 26314811
Curr Opin Rheumatol. 2017 May;29(3):254-259
pubmed: 28207496
Eur Respir Rev. 2015 Mar;24(135):1-16
pubmed: 25726549
Am J Respir Crit Care Med. 2018 Sep 1;198(5):e44-e68
pubmed: 30168753
Ann Rheum Dis. 2010 Sep;69(9):1580-8
pubmed: 20699241
Tuberc Respir Dis (Seoul). 2017 Apr;80(2):113-135
pubmed: 28416952
Am J Respir Crit Care Med. 2011 Feb 1;183(3):372-8
pubmed: 20851924
Med Sci (Basel). 2019 Feb 20;7(2):
pubmed: 30791646
Radiographics. 2007 May-Jun;27(3):595-615
pubmed: 17495281
Arthritis Rheum. 2010 Jun;62(6):1583-91
pubmed: 20155830
Adv Ther. 2017 Nov;34(11):2481-2490
pubmed: 29067557