The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation.
Aging
Cortisol
Inflammation
Metabolic syndrome
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
04
07
2019
accepted:
13
08
2019
pubmed:
1
9
2019
medline:
2
10
2020
entrez:
1
9
2019
Statut:
ppublish
Résumé
Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol). From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine). In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively. The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects. The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.
Sections du résumé
BACKGROUND
BACKGROUND
Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders.
AIMS
OBJECTIVE
To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol).
METHODS
METHODS
From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine).
RESULTS
RESULTS
In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively.
DISCUSSION
CONCLUSIONS
The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects.
CONCLUSION
CONCLUSIONS
The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.
Identifiants
pubmed: 31471891
doi: 10.1007/s40520-019-01322-3
pii: 10.1007/s40520-019-01322-3
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1309-1315Investigateurs
Paolo Falaschi
(P)
Antonio Martocchia
(A)
Manuela Stefanelli
(M)
Lavinia Toussan
(L)
Francesca Pastore
(F)
Stefano Eleuteri
(S)
Giulia Maria Falaschi
(GM)
Antonella Proietti
(A)
Rosaria D'Urso
(R)
Letizia Petricca
(L)
Patrizia Cardelli
(P)
Maurizio Gallucci
(M)
Maria Grazia Oddo
(MG)
Stefania Maggi
(S)
Marianna Noale
(M)
Demetrio Postacchini
(D)
Cinzia Giuli
(C)
Ilenia Macchiati
(I)
Monica Migale
(M)
Francesca Sorvillo
(F)
Roberto Brunelli
(R)
Monia Francavilla
(M)
Silvia Santini
(S)
Luciano Marini
(L)
Elpidio Santillo
(E)
Luca Fallavollita
(L)
Maurizio Cassol
(M)
Sara Rotunno
(S)
Giuseppe Paolisso
(G)
Michelangela Barbieri
(M)
Edith Angellotti
(E)
Claudio Ferri
(C)
Valeria Ludovici
(V)
Paola Cheli
(P)
Rita Del Pinto
(R)
Giovambattista Desideri
(G)
Mario Barbagallo
(M)
Ligia J Dominguez
(LJ)
Giovanna Di Bella
(G)
Valentino Culotta
(V)