Tolerogenic dendritic cells in organ transplantation.
dendritic cells
immune tolerance
organ transplantation
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
19
06
2019
revised:
24
07
2019
accepted:
25
08
2019
pubmed:
1
9
2019
medline:
28
5
2021
entrez:
1
9
2019
Statut:
ppublish
Résumé
Dendritic cells (DCs) are specialized cells of the innate immune system that are characterized by their ability to take up, process and present antigens (Ag) to effector T cells. They are derived from DC precursors produced in the bone marrow. Different DC subsets have been described according to lineage-specific transcription factors required for their development and function. Functionally, DCs are responsible for inducing Ag-specific immune responses that mediate organ transplant rejection. Consequently, to prevent anti-donor immune responses, therapeutic strategies have been directed toward the inhibition of DC activation. In addition however, an extensive body of preclinical research, using transplant models in rodents and nonhuman primates, has established a central role of DCs in the negative regulation of alloimmune responses. As a result, DCs have been employed as cell-based immunotherapy in early phase I/II clinical trials in organ transplantation. Together with in vivo targeting through use of myeloid cell-specific nanobiologics, DC manipulation represents a promising approach for the induction of transplantation tolerance. In this review, we summarize fundamental characteristics of DCs and their roles in promotion of central and peripheral tolerance. We also discuss their clinical application to promote improved long-term outcomes in organ transplantation.
Identifiants
pubmed: 31472079
doi: 10.1111/tri.13504
pmc: PMC6983332
mid: NIHMS1048759
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-127Subventions
Organisme : NIH HHS
ID : R01 AI 139623
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139623
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA078207
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI136779
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118777
Pays : United States
Organisme : NIH HHS
ID : R01 AI 118777
Pays : United States
Organisme : NIH HHS
ID : U19 AI 131453
Pays : United States
Organisme : NIH HHS
ID : U01 AI 136779
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI131453
Pays : United States
Informations de copyright
© 2019 Steunstichting ESOT.
Références
J Exp Med. 2002 Dec 16;196(12):1627-38
pubmed: 12486105
J Immunol. 2009 Feb 15;182(4):1877-84
pubmed: 19201840
J Evid Based Med. 2014 May;7(2):135-46
pubmed: 25155769
Blood. 2011 Mar 3;117(9):2640-8
pubmed: 21220748
Nat Immunol. 2015 Jul;16(7):718-28
pubmed: 26054720
J Immunol. 1997 Jun 15;158(12):5676-84
pubmed: 9190916
Am J Transplant. 2005 Feb;5(2):255-67
pubmed: 15643985
Transplantation. 1995 Dec 15;60(11):1366-70
pubmed: 8525540
Transplantation. 2005 Apr 27;79(8):969-72
pubmed: 15849552
Curr Opin Organ Transplant. 2014 Aug;19(4):348-56
pubmed: 24926700
Nat Rev Immunol. 2014 Mar;14(3):195-208
pubmed: 24566916
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):351-8
pubmed: 11773639
Transplantation. 2003 Feb 27;75(4):521-8
pubmed: 12605121
Sci Rep. 2016 Sep 19;6:32971
pubmed: 27640806
PLoS One. 2008 Aug 29;3(8):e3097
pubmed: 18769733
J Immunol. 2002 Sep 15;169(6):3382-91
pubmed: 12218160
Transplant Rev (Orlando). 2019 Jul;33(3):130-136
pubmed: 31130302
Diabetes. 2015 Oct;64(10):3521-31
pubmed: 26070317
Nat Commun. 2014;5:3065
pubmed: 24445279
Immunity. 2018 Nov 20;49(5):819-828.e6
pubmed: 30413362
Transplantation. 2006 May 27;81(10):1451-9
pubmed: 16732184
Nat Rev Immunol. 2012 Jul 13;12(8):557-69
pubmed: 22790179
Cold Spring Harb Perspect Med. 2013 Jul 01;3(7):null
pubmed: 23818517
Immunity. 2002 Aug;17(2):211-20
pubmed: 12196292
Annu Rev Immunol. 1991;9:271-96
pubmed: 1910679
Science. 2007 Jan 5;315(5808):107-11
pubmed: 17204652
Immunol Lett. 2014 Nov;162(1 Pt A):74-86
pubmed: 25149861
Transplantation. 1995 Dec 27;60(12):1539-45
pubmed: 8545887
Circulation. 2008 Jan 22;117(3):379-87
pubmed: 18158358
PLoS One. 2009;4(3):e4940
pubmed: 19333400
J Exp Med. 2015 Mar 9;212(3):385-99
pubmed: 25687283
Blood. 2010 Oct 14;116(15):2694-705
pubmed: 20576812
J Immunol. 2007 May 1;178(9):5480-7
pubmed: 17442929
Hum Immunol. 2018 May;79(5):314-321
pubmed: 29100944
J Immunol. 2008 Nov 15;181(10):6923-33
pubmed: 18981112
PLoS One. 2012;7(8):e44045
pubmed: 22952868
Transplantation. 2003 Nov 27;76(10):1503-10
pubmed: 14657694
FASEB J. 2009 Sep;23(9):3070-7
pubmed: 19420134
Front Immunol. 2018 Feb 19;9:274
pubmed: 29520275
Blood. 2005 Sep 1;106(5):1694-702
pubmed: 15920011
Immunology. 2005 Dec;116(4):464-76
pubmed: 16313360
J Evid Based Med. 2013 Nov;6(4):250-64
pubmed: 24325419
Mol Med. 2018 May 3;24(1):17
pubmed: 30134798
Curr Opin Immunol. 2004 Oct;16(5):550-7
pubmed: 15341998
Nat Rev Immunol. 2014 Aug;14(8):571-8
pubmed: 25033907
Transplantation. 1998 Nov 27;66(10):1285-91
pubmed: 9846510
J Exp Med. 1974 Jun 1;139(6):1431-45
pubmed: 4598015
Semin Immunopathol. 2018 Sep;40(5):477-490
pubmed: 29594331
J Immunol. 2002 Sep 1;169(5):2390-6
pubmed: 12193706
Immunol Lett. 2011 Aug 30;138(2):144-55
pubmed: 21513739
Eur J Immunol. 2001 Oct;31(10):2892-900
pubmed: 11592064
Front Immunol. 2017 Jun 09;8:657
pubmed: 28649247
J Immunol. 2000 Jan 1;164(1):161-7
pubmed: 10605007
J Control Release. 2012 May 30;160(1):72-80
pubmed: 22306335
Am J Transplant. 2006 Jul;6(7):1541-50
pubmed: 16827854
Curr Opin Immunol. 1997 Jun;9(3):351-7
pubmed: 9203408
Front Immunol. 2017 Dec 11;8:1764
pubmed: 29375543
J Exp Med. 2015 Mar 9;212(3):401-13
pubmed: 25687281
Methods Mol Biol. 2011;677:247-68
pubmed: 20941616
Front Immunol. 2017 Dec 22;8:1888
pubmed: 29312352
Immunity. 2006 Jul;25(1):153-62
pubmed: 16860764
J Biomed Mater Res A. 2008 Jun 15;85(4):983-92
pubmed: 17907241
Am J Transplant. 2005 Feb;5(2):228-36
pubmed: 15643982
Sci Rep. 2016 Jan 29;7:20077
pubmed: 26822278
Transplantation. 2008 Jan 27;85(2):237-46
pubmed: 18212629
J Biomed Mater Res A. 2008 Mar 15;84(4):885-98
pubmed: 17647224
J Control Release. 2011 Dec 10;156(2):154-60
pubmed: 21864593
Plast Reconstr Surg. 2008 Jan;121(1):37-49
pubmed: 18176204
J Immunol Methods. 2002 Dec 15;270(2):211-26
pubmed: 12379326
Nat Immunol. 2009 Sep;10(9):981-91
pubmed: 19668220
Transpl Int. 2017 Aug;30(8):754-764
pubmed: 27864897
Cell Mol Immunol. 2015 Jan;12(1):24-30
pubmed: 25109681
Nat Rev Immunol. 2013 Aug;13(8):592-605
pubmed: 23883969
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1099-1104
pubmed: 28096390
Mol Immunol. 2016 Nov;79:92-97
pubmed: 27764710
Immunol Lett. 2003 Nov 15;90(1):33-42
pubmed: 14611905
Am J Transplant. 2011 Oct;11(10):2036-45
pubmed: 21794083
Transplantation. 1996 Sep 15;62(5):659-65
pubmed: 8830833
Clin Biochem. 1997 Mar;30(2):135-42
pubmed: 9127695
J Immunol. 1996 Aug 15;157(4):1406-14
pubmed: 8759720
J Immunol. 2004 Oct 15;173(8):4828-37
pubmed: 15470023
Immunity. 2014 May 15;40(5):642-56
pubmed: 24837101
J Clin Invest. 2018 Nov 1;128(11):4770-4786
pubmed: 30277476
Hepatology. 2018 Apr;67(4):1499-1515
pubmed: 28921638
Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):116-131
pubmed: 27133387
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6800-5
pubmed: 11371626
Drug Deliv. 2009 Jan;16(1):15-23
pubmed: 19555304
Rev Diabet Stud. 2010 Spring;7(1):47-61
pubmed: 20703438
Cancer Immunol Res. 2013 Sep;1(3):145-9
pubmed: 24777676
J Immunol. 2007 Jun 1;178(11):7018-31
pubmed: 17513751
J Surg Res. 2011 Dec;171(2):826-32
pubmed: 20828738
Nat Rev Immunol. 2004 Jan;4(1):24-34
pubmed: 14704765
J Immunol. 2003 Feb 1;170(3):1304-12
pubmed: 12538690
J Immunol. 2006 Jul 15;177(2):863-8
pubmed: 16818740
Transplantation. 2016 Jan;100(1):91-102
pubmed: 26680373
J Immunol. 2010 Feb 15;184(4):1757-64
pubmed: 20083658
Clin Exp Immunol. 2014 Apr;176(1):37-48
pubmed: 24266626
Ann Surg. 2005 Mar;241(3):497-505
pubmed: 15729074
Am J Transplant. 2011 Dec;11(12):2582-92
pubmed: 21883921
Int J Pharm. 2014 Jan 2;460(1-2):173-80
pubmed: 24172796
J Immunol. 2014 Jun 1;192(11):5426-33
pubmed: 24790149
Front Immunol. 2017 Nov 20;8:1514
pubmed: 29250057
Nat Med. 2013 Jun;19(6):739-46
pubmed: 23624599
Am J Transplant. 2006 Jun;6(6):1297-311
pubmed: 16686754
Front Immunol. 2012 Aug 09;3:218
pubmed: 22908013
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E156-65
pubmed: 25548186
Am J Transplant. 2014 May;14(5):1021-1031
pubmed: 24731243
J Exp Med. 2009 Mar 16;206(3):549-59
pubmed: 19237601
J Immunol. 2010 Nov 1;185(9):5003-10
pubmed: 20870943
J Exp Med. 2011 Nov 21;208(12):2477-88
pubmed: 22025302
Immunity. 2010 Apr 23;32(4):568-80
pubmed: 20381385
J Immunol. 2001 Mar 15;166(6):3717-23
pubmed: 11238612
Front Immunol. 2018 Feb 20;9:230
pubmed: 29515571
Am J Transplant. 2001 Jul;1(2):129-37
pubmed: 12099360
Am J Transplant. 2013 Aug;13(8):1989-2005
pubmed: 23758811
J Immunol. 2003 Aug 15;171(4):1652-5
pubmed: 12902462
Proc Natl Acad Sci U S A. 1982 Jan;79(1):161-5
pubmed: 6948298
Nat Med. 2012 Jun;18(6):883-91
pubmed: 22635005
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11270-5
pubmed: 22745170
J Exp Med. 1990 May 1;171(5):1753-71
pubmed: 2185332
Transpl Int. 2006 Jul;19(7):525-38
pubmed: 16764631
Transplantation. 2018 Oct;102(10):1603-1613
pubmed: 29677072
Endocrinology. 2010 Feb;151(2):458-65
pubmed: 20016026
J Exp Med. 2012 Jan 16;209(1):109-21
pubmed: 22213806
Nat Mater. 2014 Feb;13(2):125-38
pubmed: 24452356
Eur J Immunol. 2000 Jul;30(7):1813-22
pubmed: 10940870
Transplantation. 1999 Dec 27;68(12):1827-34
pubmed: 10628758
Cell Death Differ. 2004 Dec;11(12):1258-64
pubmed: 15375386
Biomaterials. 2014 Oct;35(31):8887-8894
pubmed: 25066477
Nat Nanotechnol. 2016 Oct;11(10):890-899
pubmed: 27479756
J Clin Invest. 2016 Aug 1;126(8):2805-20
pubmed: 27348586
Cell Immunol. 2018 Jan;323:9-18
pubmed: 29217299
Sci Immunol. 2016 Jul 14;1(1):
pubmed: 27942611
J Immunol. 2002 Feb 1;168(3):1080-6
pubmed: 11801641
J Nucl Med. 2015 Aug;56(8):1272-7
pubmed: 26112022
J Lipid Res. 2013 Sep;54(9):2450-7
pubmed: 23812625
Transplantation. 1999 Sep 27;68(6):747-57
pubmed: 10515374
Nat Rev Immunol. 2007 Aug;7(8):610-21
pubmed: 17627284
J Immunol. 2010 Mar 1;184(5):2329-36
pubmed: 20139277
Semin Immunol. 2011 Aug;23(4):252-63
pubmed: 21741270
J Exp Med. 1973 May 1;137(5):1142-62
pubmed: 4573839
Front Immunol. 2018 Oct 17;9:2409
pubmed: 30386346
J Cell Biochem. 2003 Feb 1;88(2):227-33
pubmed: 12520519
J Clin Invest. 2013 Feb;123(2):844-54
pubmed: 23298832
J Am Soc Nephrol. 2004 Apr;15(4):987-97
pubmed: 15034101
Blood. 2012 Jul 19;120(3):581-91
pubmed: 22692512