Sex-specific changes in the aphid DNA methylation landscape.
Myzus persicae
dosage compensation
epigenetic regulation
sex chromosome
sex-biased gene expression
Journal
Molecular ecology
ISSN: 1365-294X
Titre abrégé: Mol Ecol
Pays: England
ID NLM: 9214478
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
18
06
2018
accepted:
22
07
2019
pubmed:
1
9
2019
medline:
12
6
2020
entrez:
1
9
2019
Statut:
ppublish
Résumé
Aphids present an ideal system to study epigenetics as they can produce diverse, but genetically identical, morphs in response to environmental stimuli. Here, using whole genome bisulphite sequencing and transcriptome sequencing of the green peach aphid (Myzus persicae), we present the first detailed analysis of cytosine methylation in an aphid and investigate differences in the methylation and transcriptional landscapes of male and asexual female morphs. We found that methylation primarily occurs in a CG dinucleotide (CpG) context and that exons are highly enriched for methylated CpGs, particularly at the 3' end of genes. Methylation is positively associated with gene expression, and methylated genes are more stably expressed than unmethylated genes. Male and asexual female morphs have distinct methylation profiles. Strikingly, these profiles are divergent between the sex chromosome and the autosomes; autosomal genes are hypomethylated in males compared to asexual females, whereas genes belonging to the sex chromosome, which is haploid in males, are hypermethylated. Overall, we found correlated changes in methylation and gene expression between males and asexual females, and this correlation was particularly strong for genes located on the sex chromosome. Our results suggest that differential methylation of sex-biased genes plays a role in aphid sexual differentiation.
Identifiants
pubmed: 31472081
doi: 10.1111/mec.15216
pmc: PMC6857007
doi:
Banques de données
GENBANK
['PRJNA437622']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4228-4241Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/CCG1720/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L002108/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N02317X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P012574/1
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.
Références
Nature. 2015 Mar 26;519(7544):464-7
pubmed: 25799997
Experientia. 1971 Jun;27(6):704-6
pubmed: 5556464
Mol Biol Evol. 2016 Feb;33(2):568-84
pubmed: 26538142
Am Nat. 2009 Feb;173(2):141-50
pubmed: 20374139
PLoS One. 2011;6(7):e21800
pubmed: 21789182
Genet Res. 2001 Jun;77(3):251-60
pubmed: 11486508
Science. 2006 Jan 20;311(5759):395-8
pubmed: 16424344
Bioinformatics. 2011 Jun 1;27(11):1571-2
pubmed: 21493656
Ecol Evol. 2013 Jun;3(6):1819-34
pubmed: 23789088
Genetics. 2017 Nov;207(3):1067-1078
pubmed: 28951528
Bioinformatics. 2014 Oct;30(19):2808-10
pubmed: 24903420
PLoS Genet. 2013;9(8):e1003690
pubmed: 23950732
Evol Lett. 2018 Feb 10;2(2):52-61
pubmed: 30283664
Nat Rev Genet. 2010 Mar;11(3):204-20
pubmed: 20142834
PLoS Genet. 2014 Dec 11;10(12):e1004868
pubmed: 25501653
Genet Res Int. 2012;2012:431531
pubmed: 22567389
Evolution. 1984 Jul;38(4):735-742
pubmed: 28555827
Genome Biol Evol. 2018 Feb 1;10(2):507-520
pubmed: 29360959
Nature. 2007 Nov 8;450(7167):233-7
pubmed: 17994089
BMC Genomics. 2015 Jun 05;16:429
pubmed: 26044338
Mol Biol Evol. 2019 Jul 1;36(7):1481-1489
pubmed: 30989224
Nat Rev Genet. 2016 Aug;17(8):487-500
pubmed: 27346641
Nat Biotechnol. 2010 May;28(5):516-20
pubmed: 20436463
Science. 2014 Nov 7;346(6210):763-7
pubmed: 25378627
Bull Entomol Res. 1971 Jun;60(4):533-46
pubmed: 22894860
Curr Biol. 2010 Sep 14;20(17):R780-5
pubmed: 20833323
Nat Rev Genet. 2014 Oct;15(10):677-88
pubmed: 25200663
Nature. 2014 Jul 31;511(7511):606-10
pubmed: 25079557
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8689-94
pubmed: 20395551
Genome Biol. 2017 May 1;18(1):65
pubmed: 28457232
Sci Rep. 2016 Nov 16;6:37110
pubmed: 27848993
Annu Rev Genet. 2010;44:91-112
pubmed: 21047257
Epigenetics Chromatin. 2017 Jun 15;10:30
pubmed: 28638443
Nat Neurosci. 2012 Oct;15(10):1371-3
pubmed: 22983211
Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):581-6
pubmed: 12522265
Annu Rev Genet. 2016 Nov 23;50:29-44
pubmed: 27574843
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
Mol Ecol. 2019 Sep;28(18):4228-4241
pubmed: 31472081
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6796-9
pubmed: 25368180
Genome Biol. 2012 Oct 03;13(10):R87
pubmed: 23034086
J Hered. 2017 Jan;108(1):78-93
pubmed: 27543823
Mol Biol Evol. 2014 Aug;31(8):2073-83
pubmed: 24770714
Bioinformatics. 2011 Jan 15;27(2):225-31
pubmed: 21098430
Insect Mol Biol. 2010 Mar;19 Suppl 2:215-28
pubmed: 20482652
Curr Biol. 2012 Nov 20;22(22):2167-72
pubmed: 23103191
Bioinformatics. 2005 Aug 15;21(16):3448-9
pubmed: 15972284
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3545-54
pubmed: 26100871
Science. 2010 May 14;328(5980):916-9
pubmed: 20395474
Mol Biol Evol. 2017 Mar 1;34(3):654-665
pubmed: 28025279
Nat Rev Genet. 2007 Sep;8(9):689-98
pubmed: 17680007
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Genetics. 2014 Jul;197(3):865-83
pubmed: 24793291
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13970-5
pubmed: 26483466
Sci Adv. 2018 Jun 06;4(6):eaar8028
pubmed: 29881778
Nat Rev Genet. 2008 Jun;9(6):465-76
pubmed: 18463664
Nat Rev Genet. 2015 Feb;16(2):71-84
pubmed: 25554358
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
PLoS Genet. 2013;9(10):e1003872
pubmed: 24130511
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3810-9
pubmed: 24043781
Curr Biol. 2016 Feb 8;26(3):391-5
pubmed: 26804553
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Nat Genet. 2006 Dec;38(12):1378-85
pubmed: 17072317
Genome Biol. 2017 Feb 13;18(1):27
pubmed: 28190401
Genome Biol. 2008 Apr 30;9(4):R76
pubmed: 18447906
Insect Mol Biol. 2004 Apr;13(2):109-15
pubmed: 15056357
Curr Biol. 2012 Oct 9;22(19):1755-64
pubmed: 22885060
Genome Res. 2017 Sep;27(9):1536-1548
pubmed: 28747381
Genome Biol Evol. 2010;2:719-28
pubmed: 20855427
Nature. 2015 Jan 15;517(7534):321-6
pubmed: 25592537