Zebrafish as a Model of Neurodevelopmental Disorders.

Animals Brain Disease Models, Animal Humans Models, Animal Neurodevelopmental Disorders Quality of Life Zebrafish
animal models attention-deficit/hyperactivity disorder autism genetic models neurodevelopment

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 10 2020
Historique:
received: 19 04 2019
revised: 21 07 2019
accepted: 20 08 2019
pubmed: 1 9 2019
medline: 15 5 2021
entrez: 1 9 2019
Statut: ppublish

Résumé

Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs, possessing both high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments.

Identifiants

DOI: 10.1016/j.neuroscience.2019.08.034 PMID: 31472215
pubmed: 31472215
pii: S0306-4522(19)30607-4
doi: 10.1016/j.neuroscience.2019.08.034
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

3-11

Informations de copyright

Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare no conflict of interest.

Auteurs

Murilo S de Abreu (MS)

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address: abreu_murilo@hotmail.com.

Rafael Genario (R)

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.

Ana C V V Giacomini (ACVV)

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Program in Environmental Sciences, University of Passo Fundo, Passo Fundo, Brazil.

Konstantin A Demin (KA)

Institute of Experimental Medicine, Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.

Anton M Lakstygal (AM)

Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Granov Russian Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia.

Tamara G Amstislavskaya (TG)

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.

Barbara Dotto Fontana (BD)

Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UK.

Matthew O Parker (MO)

Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UK.

Allan V Kalueff (AV)

School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Zebrafish as a Model of Neurodevelopmental Disorders.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Zebrafish as a Model of Neurodevelopmental Disorders.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Zebrafish as a Model of Neurodevelopmental Disorders.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Zebrafish as a Model of Neurodevelopmental Disorders.
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Zebrafish as a Model of Neurodevelopmental Disorders.
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Zebrafish as a Model of Neurodevelopmental Disorders.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Zebrafish as a Model of Neurodevelopmental Disorders.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Zebrafish as a Model of Neurodevelopmental Disorders.