Lessons learned from quantitative fundus autofluorescence.
ABCA4
Acute zonal occult outer retinopathy
Age-related macular degeneration
Confocal scanning laser ophthalmoscopy
Fundus
Fundus autofluorescence
Quantitative fundus autofluorescence
Recessive stargardt disease
Retina
Retinitis pigmentosa
Journal
Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
21
05
2019
revised:
21
08
2019
accepted:
25
08
2019
pubmed:
1
9
2019
medline:
4
2
2021
entrez:
1
9
2019
Statut:
ppublish
Résumé
Quantitative fundus autofluorescence (qAF) is an approach that is built on a confocal scanning laser platform and used to measure the intensity of the inherent autofluorescence of retina elicited by short-wavelength (488 nm) excitation. Being non-invasive, qAF does not interrupt tissue architecture, thus allowing for structural correlations. The spectral features, cellular origin and topographic distribution of the natural autofluorescence of the fundus indicate that it is emitted from retinaldehyde-adducts that form in photoreceptor cells and accumulate, under most conditions, in retinal pigment epithelial cells. The distributions and intensities of fundus autofluorescence deviate from normal in many retinal disorders and it is widely recognized that these changing patterns can aid in the diagnosis and monitoring of retinal disease. The standardized protocol employed by qAF involves the normalization of fundus grey levels to a fluorescent reference installed in the imaging instrument. Together with corrections for magnification and anterior media absorption, this approach facilitates comparisons with serial images and images acquired within groups of patients. Here we provide a comprehensive summary of the principles and practice of qAF and we highlight recent efforts to elucidate retinal disease processes by combining qAF with multi-modal imaging.
Identifiants
pubmed: 31472235
pii: S1350-9462(19)30033-3
doi: 10.1016/j.preteyeres.2019.100774
pmc: PMC7561015
mid: NIHMS1631726
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100774Subventions
Organisme : NEI NIH HHS
ID : P30 EY019007
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY024091
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
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