Antiplasmodial activity of triterpenes isolated from the methanolic leaf extract of Combretum racemosum P. Beauv.
Africa, Western
Animals
Antimalarials
/ isolation & purification
Combretum
/ chemistry
Ethnopharmacology
Humans
Malaria
/ drug therapy
Medicine, African Traditional
/ methods
Methanol
/ chemistry
Parasitic Sensitivity Tests
Plant Extracts
/ isolation & purification
Plasmodium falciparum
/ drug effects
Triterpenes
/ isolation & purification
Antiplasmodial activity
Combretum racemosum
Isolation
Madecassic acid
Triterpenes
Journal
Journal of ethnopharmacology
ISSN: 1872-7573
Titre abrégé: J Ethnopharmacol
Pays: Ireland
ID NLM: 7903310
Informations de publication
Date de publication:
30 Jan 2020
30 Jan 2020
Historique:
received:
27
05
2019
revised:
21
08
2019
accepted:
28
08
2019
pubmed:
1
9
2019
medline:
24
3
2020
entrez:
1
9
2019
Statut:
ppublish
Résumé
Combretum racemosum showed activity in previous ethnopharmacological investigations of some Combretum species used in malaria treatment in parts of West Africa. This study aimed at confirming the antimalarial potential of this plant by an activity-guided isolation of its active principles. A crude methanolic leaf extract of Combretum racemosum and fractions thereof obtained by partition with chloroform and n-butanol were investigated for antiplasmodial activity against chloroquine-sensitive (D10) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Repeated chromatographic separations were conducted on the chloroform fraction to isolate bioactive compounds for further tests on antiplasmodial activity. The characterization of the isolated substances was performed by applying NMR- and MS-techniques (ESI-MS, HR-ESIMS, 1D and 2D NMR). The chloroform fraction (D10: IC This paper reports for the first time antiplasmodial principles from C. racemosum and thereby gives reason to the traditional use of the plant.
Identifiants
pubmed: 31472271
pii: S0378-8741(19)31956-7
doi: 10.1016/j.jep.2019.112203
pii:
doi:
Substances chimiques
Antimalarials
0
Plant Extracts
0
Triterpenes
0
Methanol
Y4S76JWI15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112203Informations de copyright
Copyright © 2019. Published by Elsevier B.V.