Antibacterial stilbenes from the tubers of Bletilla striata.
Anti-Bacterial Agents
/ isolation & purification
Bibenzyls
/ isolation & purification
China
Microbial Sensitivity Tests
Molecular Structure
Orchidaceae
/ chemistry
Phytochemicals
/ isolation & purification
Plant Tubers
/ chemistry
Staphylococcus aureus
/ drug effects
Stilbenes
/ isolation & purification
Antibacterial activities
Bibenzyls
Bletilla striata
Phenanthrenes
Stilbenoids
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
25
07
2019
revised:
28
08
2019
accepted:
29
08
2019
pubmed:
2
9
2019
medline:
4
12
2019
entrez:
2
9
2019
Statut:
ppublish
Résumé
Three new bibenzyl derivatives (bletstrins A-C, 1-3), including two bibenzyls that have hydroxyl-substituted chiral centers on the aliphatic bibenzyl bridge, along with eighteen known stilbenoids (4-21) were isolated from the tubers of Bletilla striata. The structures of new compounds were elucidated by the use of 1D/2D NMR spectroscopic data. The absolute configurations of bletitrins A and B were determined by optical rotation value. Compounds 13-16 were isolated from the Orchidaceae for the first time. Most of the isolated compounds were evaluated for their antibacterial activities against three gram-positive bacterial strains and one gram-negative bacterial strain. Compounds 4, 10, 12, 14, 15, 16 and 18 showed potent inhibitory activities, with MICs of (6-52 μg/mL) against S. aureus ATCC 6538.
Identifiants
pubmed: 31473333
pii: S0367-326X(19)31521-7
doi: 10.1016/j.fitote.2019.104350
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bibenzyls
0
Phytochemicals
0
Stilbenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104350Informations de copyright
Copyright © 2019. Published by Elsevier B.V.