Resting-state fMRI dynamic functional network connectivity and associations with psychopathy traits.
Dynamic functional network connectivity
Group independent component analysis
K-means clustering
Psychopathy
Resting-state fMRI
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
02
2019
revised:
25
07
2019
accepted:
03
08
2019
pubmed:
2
9
2019
medline:
22
9
2020
entrez:
2
9
2019
Statut:
ppublish
Résumé
Studies have used resting-state functional magnetic resonance imaging (rs-fMRI) to examine associations between psychopathy and brain connectivity in selected regions of interest as well as networks covering the whole-brain. One of the limitations of these approaches is that brain connectivity is modeled as a constant state through the scan duration. To address this limitation, we apply group independent component analysis (GICA) and dynamic functional network connectivity (dFNC) analysis to uncover whole-brain, time-varying functional network connectivity (FNC) states in a large forensic sample. We then examined relationships between psychopathic traits (PCL-R total scores, Factor 1 and Factor 2 scores) and FNC states obtained from dFNC analysis. FNC over the scan duration was better represented by five states rather than one state previously shown in static FNC analysis. Consistent with prior findings, psychopathy was associated with networks from paralimbic regions (amygdala and insula). In addition, whole-brain FNC identified 15 networks from nine functional domains (subcortical, auditory, sensorimotor, cerebellar, visual, salience, default mode network, executive control and attentional) related to psychopathy traits (Factor 1 and PCL-R scores). Results also showed that individuals with higher Factor 1 scores (affective and interpersonal traits) spend more time in a state with weaker connectivity overall, and changed states less frequently compared to those with lower Factor 1 scores. On the other hand, individuals with higher Factor 2 scores (impulsive and antisocial behaviors) showed more dynamism (changes to and from different states) than those with lower scores.
Identifiants
pubmed: 31473543
pii: S2213-1582(19)30320-1
doi: 10.1016/j.nicl.2019.101970
pmc: PMC6728837
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
101970Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103472
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH109329
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM122734
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH090169
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH070539
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH087525
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA026505
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA020870
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH114028
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA026964
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB020407
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026290
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS054893
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Curr Psychiatry Rep. 2005 Mar;7(1):57-64
pubmed: 15717988
J Neurosci. 2011 Nov 30;31(48):17348-57
pubmed: 22131397
Psychol Rev. 2015 Oct;122(4):770-91
pubmed: 26437150
Psychiatry Res. 2006 Jun 15;142(2-3):107-28
pubmed: 16712954
Neuroscience. 2003;118(4):1099-120
pubmed: 12732254
Front Neurosci. 2016 Feb 02;10:17
pubmed: 26869874
Cogn Affect Behav Neurosci. 2018 Jun;18(3):564-580
pubmed: 29633199
J Neurosci. 2015 Apr 15;35(15):6068-78
pubmed: 25878280
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5
pubmed: 19620724
Neuroimage. 2014 Aug 15;97:117-26
pubmed: 24736181
Neuropsychol Rev. 2014 Mar;24(1):3-15
pubmed: 24496902
Prog Brain Res. 2004;144:171-82
pubmed: 14650848
Hum Brain Mapp. 2018 Jun;39(6):2624-2634
pubmed: 29498761
Hum Brain Mapp. 2001 Nov;14(3):140-51
pubmed: 11559959
Cereb Cortex. 2014 Mar;24(3):663-76
pubmed: 23146964
Neuron. 2014 Oct 22;84(2):262-74
pubmed: 25374354
Hum Brain Mapp. 2011 Dec;32(12):2075-95
pubmed: 21162045
Med Image Anal. 2012 Feb;16(2):451-8
pubmed: 22155195
MAGMA. 2010 Dec;23(5-6):351-66
pubmed: 20162320
Front Syst Neurosci. 2011 Feb 04;5:2
pubmed: 21442040
PLoS One. 2013 Aug 20;8(8):e72375
pubmed: 23977291
Biostatistics. 2008 Jul;9(3):432-41
pubmed: 18079126
BMC Neurosci. 2009 Nov 23;10:137
pubmed: 19930640
Neuroimage. 2011 Jan 15;54(2):875-91
pubmed: 20817103
Philos Trans R Soc Lond B Biol Sci. 2008 Aug 12;363(1503):2557-65
pubmed: 18434283
Brain Res. 2009 Dec 15;1303:195-206
pubmed: 19699190
Trends Cogn Sci. 2005 Dec;9(12):585-94
pubmed: 16289871
Cogn Affect Behav Neurosci. 2017 Jun;17(3):491-515
pubmed: 28092055
Biol Psychiatry. 2018 Apr 15;83(8):638-647
pubmed: 29275839
Can J Psychiatry. 2009 Dec;54(12):813-23
pubmed: 20047720
Soc Cogn Affect Neurosci. 2017 Jul 1;12(7):1169-1178
pubmed: 28402565
Hum Brain Mapp. 2013 Aug;34(8):1921-30
pubmed: 22431294
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):149-157
pubmed: 28367514
J Abnorm Psychol. 2012 Aug;121(3):649-58
pubmed: 22149911
Trends Cogn Sci. 2012 Jan;16(1):52-60
pubmed: 22177031
Hum Brain Mapp. 2015 Oct;36(10):4202-9
pubmed: 26219745
Schizophr Res. 2008 Apr;101(1-3):95-105
pubmed: 18378428
Neuroimage. 2015 Oct 15;120:133-42
pubmed: 26162552
Biol Psychiatry. 2010 Jan 1;67(1):66-70
pubmed: 19793581
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Neuroimage. 2013 Oct 15;80:360-78
pubmed: 23707587
Hum Brain Mapp. 2015 Apr;36(4):1417-28
pubmed: 25557777
Arch Gen Psychiatry. 2003 Nov;60(11):1134-42
pubmed: 14609889