Low-Grade Papillary Schneiderian Carcinoma: Report of a Case with Molecular Characterization.
Inverted papilloma
Schneiderian papilloma
Sinonasal epithelium
Sinonasal papillary carcinoma
Journal
Head and neck pathology
ISSN: 1936-0568
Titre abrégé: Head Neck Pathol
Pays: United States
ID NLM: 101304010
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
08
07
2019
accepted:
12
08
2019
pubmed:
2
9
2019
medline:
4
6
2021
entrez:
2
9
2019
Statut:
ppublish
Résumé
In 2015, Lewis et al. first described low-grade papillary Scheneiderian carcinoma (LGPSC) of the sinonasal tract. Their case resembled a sinonasal papilloma clinically and histopathologically; however, invasion and metastasis resulted in the death of the patient despite absence of malignant cytologic features. Additional reports established LGPSC as a distinct entity and characterized its immunohistochemical profile. Diffuse expression of low molecular weight cytokeratins, positivity for p16 and p53 in at least 50% of cells, a high Ki-67 index, and absence of human papillomavirus (HPV)-DNA was observed across all reported cases. We report an additional case of LGPSC and describe the clinical, histologic, and immunohistochemical features. In contrast to sinonasal papillomas, the case was negative for HPV-DNA and showed no mutations in the EGFR and KRAS hotspot regions.
Identifiants
pubmed: 31473940
doi: 10.1007/s12105-019-01067-5
pii: 10.1007/s12105-019-01067-5
pmc: PMC7413950
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
799-802Références
Udager AM, McHugh JB, Goudsmit CM, et al. Human papillomavirus (HPV) and somatic EGFR mutations are essential, mutually exclusive oncogenic mechanisms for inverted sinonasal papillomas and associated sinonasal squamous cell carcinomas. Ann Oncol. 2018;29:466–71.
doi: 10.1093/annonc/mdx736
Bishop JA, Bell D, Westra WH. Carcinomas of the nasal cavity, paranasal sinuses and skull base. In: El-Naggar AK, editor. World Health Organization classification of head and neck tumours. Lyon: IARC Press; 2017. p. 14–26.
Nudell J, Chiosea S, Thompson LD. Carcinoma ex-schneiderian papilloma (malignant transformation): a clinicopathologic and immunophenotypic study of 20 cases combined with a comprehensive review of the literature. Head Neck Pathol. 2014;8:269–86.
doi: 10.1007/s12105-014-0527-7
pmcid: 4126921
Udager AM, Rolland DCM, McHugh JB, et al. High-frequency targetable EGFR mutations in sinonasal squamous cell carcinomas arising from inverted sinonasal papilloma. Cancer Res. 2015;75:2600–6.
doi: 10.1158/0008-5472.CAN-15-0340
pmcid: 4508878
Lewis JS, Chernock RD, Haynes W, et al. Low-grade papillary schneiderian carcinoma, a unique and deceptively bland malignant neoplasm. Am J Surg Pathol. 2015;39–5:714–21.
doi: 10.1097/PAS.0000000000000390
Jeong HJ, Roh J, Lee BJ, Cho KJ. Low-grade papillary schneiderian carcinoma: a case report. Head Neck Pathol. 2018;12:131–5.
doi: 10.1007/s12105-017-0832-z
Brown CS, Abi Hachem R, Pendse A, Madden JF, Francis HW. Low-Grade papillary schneiderian carcinoma of the sinonasal cavity and temporal bone. Ann Otol Rhinol Laryngol. 2018;127:974–7.
doi: 10.1177/0003489418803391
Williamson A, Sharma R, Cooper L, McGarry G. Low-grade schneiderian carcinoma: rare or underecognised? Otolaryngol Case Rep. 2019;11:100107.
doi: 10.1016/j.xocr.2019.02.001
Morbini P, Dal Bello B, Alberizzi P, et al. Oral HPV infection and persistence in patients with head and neck cancer. Oral Surg Oral Med. 2013;116:474–84.
Udager AM, McHugh JB, Betz BL, et al. Activating KRAS mutations are characteristic of oncocytic sinonasal papilloma and associated sinonasal squamous cell carcinoma. J Pathol. 2016;239:394–8.
doi: 10.1002/path.4750
Shah AA, Evans MF, Adamson CS, Peng Z, Rajendran V, Cooper K. HPV DNA is associated with a subset of Schneiderian papillomas but does not correlate with p16(INK4a) immunoreactivity. Head Neck Pathol. 2010;4:106–12.
doi: 10.1007/s12105-010-0176-4
pmcid: 2878630