The CNS Immune Landscape from the Viewpoint of a T Cell.
B cells
CNS leukocytes
T cells
antigen presentation
blood–brain barrier
border-associated macrophages
central nervous system
dendritic cells
immunopathology
inflammation
microglia
monocytes
neuroimmunology
phagocytes
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
26
04
2019
revised:
25
07
2019
accepted:
26
07
2019
pubmed:
3
9
2019
medline:
26
9
2020
entrez:
3
9
2019
Statut:
ppublish
Résumé
Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but also appear to influence brain development and homeostasis. During immune surveillance, T cells can patrol the CNS-associated border regions to sense pathogenic alterations. While access to the CNS parenchyma is restricted in the steady state, various disease processes can initiate parenchymal T cell CNS invasion. However, to breach the glia limitans, T cells must become reactivated within the meningeal spaces. T cells cannot sense native antigens (Ags), but instead recognize small processed peptides bound to MHC molecules and presented on the surface of Ag-presenting cells (APCs). In this review, we focus on (CD4
Identifiants
pubmed: 31474310
pii: S0166-2236(19)30131-6
doi: 10.1016/j.tins.2019.07.008
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
667-679Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.