The Sensorimotor Basis of Whisker-Guided Anteroposterior Object Localization in Head-Fixed Mice.
barrel cortex
head-fixed
localization
mouse
quantitative behavior
sensorimotor integration
somatosensation
statistical learning
touch
whisking
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
23 09 2019
23 09 2019
Historique:
received:
10
05
2019
revised:
26
06
2019
accepted:
23
07
2019
pubmed:
3
9
2019
medline:
4
8
2020
entrez:
3
9
2019
Statut:
ppublish
Résumé
Active tactile perception combines directed motion with sensory signals to generate mental representations of objects in space. Competing models exist for how mice use these signals to determine the precise location of objects along their face. We tested six of these models using behavioral manipulations and statistical learning in head-fixed mice. Trained mice used a whisker to locate a pole in a continuous range of locations along the anteroposterior axis. Mice discriminated locations to ≤0.5 mm (<2°) resolution. Their motor program was noisy, adaptive to touch, and directed to the rewarded range. This exploration produced several sets of sensorimotor features that could discriminate location. Integration of two features, touch count and whisking midpoint at touch, was the simplest model that explained behavior best. These results show how mice locate objects at hyperacute resolution using a learned motor strategy and minimal set of mentally accessible sensorimotor features.
Identifiants
pubmed: 31474537
pii: S0960-9822(19)30948-0
doi: 10.1016/j.cub.2019.07.068
pmc: PMC6771421
mid: NIHMS1049141
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3029-3040.e4Subventions
Organisme : NINDS NIH HHS
ID : DP2 NS105554
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102808
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
J Neurosci. 2001 Aug 1;21(15):5752-63
pubmed: 11466447
J Neurophysiol. 2001 Oct;86(4):1916-36
pubmed: 11600651
Neuron. 2003 Oct 30;40(3):621-30
pubmed: 14642284
J Neurosci. 2006 Aug 16;26(33):8451-64
pubmed: 16914670
Neuron. 2007 Jan 4;53(1):117-33
pubmed: 17196535
PLoS Biol. 2007 Feb;5(2):e15
pubmed: 17227143
Proc Biol Sci. 2007 Apr 22;274(1613):1035-41
pubmed: 17331893
J Neurophysiol. 2007 Oct;98(4):2439-55
pubmed: 17553946
J Neurosci. 2008 Mar 26;28(13):3438-55
pubmed: 18367610
Neuron. 2008 Jul 10;59(1):35-42
pubmed: 18614027
J Neurophysiol. 2009 Apr;101(4):1836-46
pubmed: 19109457
Nature. 2009 Feb 26;457(7233):1142-5
pubmed: 19151697
Nat Neurosci. 2009 Apr;12(4):492-501
pubmed: 19270688
J Neurosci. 2010 Feb 3;30(5):1947-67
pubmed: 20130203
PLoS Biol. 2011 Jan 04;9(1):e1000572
pubmed: 21245906
Philos Trans R Soc Lond B Biol Sci. 2011 Nov 12;366(1581):3049-57
pubmed: 21969686
Neuron. 2011 Oct 20;72(2):344-56
pubmed: 22017992
Neuron. 2011 Nov 3;72(3):455-68
pubmed: 22078505
PLoS Comput Biol. 2012;8(7):e1002591
pubmed: 22792058
Nature. 2012 Sep 13;489(7415):299-303
pubmed: 22922646
Front Behav Neurosci. 2012 Nov 06;6:74
pubmed: 23133410
Nature. 2012 Dec 13;492(7428):247-51
pubmed: 23143335
Science. 2013 Apr 5;340(6128):95-8
pubmed: 23559254
Nat Neurosci. 2013 May;16(5):622-31
pubmed: 23563582
J Neurosci. 2013 Apr 17;33(16):6726-41
pubmed: 23595731
Nat Neurosci. 2013 Jul;16(7):958-65
pubmed: 23727820
PLoS Comput Biol. 2013;9(9):e1003236
pubmed: 24086120
Elife. 2013 Nov 19;2:e01350
pubmed: 24252879
PLoS One. 2014 Feb 10;9(2):e88678
pubmed: 24520413
J Neurophysiol. 2015 Jan 15;113(2):620-32
pubmed: 25339711
Nat Neurosci. 2015 Aug;18(8):1101-8
pubmed: 26098757
Elife. 2015 Aug 06;4:null
pubmed: 26245232
PLoS Biol. 2015 Sep 22;13(9):e1002253
pubmed: 26393890
Nat Neurosci. 2016 Mar;19(3):487-93
pubmed: 26780508
J Neurophysiol. 2016 Apr;115(4):1797-809
pubmed: 26792880
Elife. 2016 Feb 15;5:null
pubmed: 26880559
Elife. 2016 May 09;5:
pubmed: 27159238
J Neurophysiol. 2016 Aug 1;116(2):812-24
pubmed: 27250911
Elife. 2016 Jun 27;5:
pubmed: 27348221
Front Behav Neurosci. 2016 Jul 19;10:145
pubmed: 27486390
J Neurophysiol. 2017 Apr 1;117(4):1807-1820
pubmed: 27881718
Neuron. 2017 Feb 8;93(3):480-490
pubmed: 28182904
Neuron. 2017 May 3;94(3):666-676.e9
pubmed: 28434802
Neuron. 2017 Jun 21;94(6):1220-1233.e5
pubmed: 28504117
PLoS One. 2017 Jun 2;12(6):e0177678
pubmed: 28574989
PLoS Comput Biol. 2017 Jun 7;13(6):e1005576
pubmed: 28591219
Neuron. 2018 Jan 17;97(2):418-433.e5
pubmed: 29307709
PLoS Comput Biol. 2018 Mar 27;14(3):e1006032
pubmed: 29584719
Nat Neurosci. 2018 Nov;21(11):1583-1590
pubmed: 30349100
J Neurosci. 2019 May 15;39(20):3921-3933
pubmed: 30850514
Curr Biol. 2019 May 6;29(9):1415-1424.e5
pubmed: 31006570
Curr Biol. 2019 May 6;29(9):1425-1435.e5
pubmed: 31006571
Anim Behav. 1972 Feb;20(1):10-2
pubmed: 4677163
J Neurophysiol. 1968 Jan;31(1):14-27
pubmed: 4966614
J Neurophysiol. 1997 Aug;78(2):1144-9
pubmed: 9307141