Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na

Na+-K+-Cl– cotransporter blood pressure blood pressure dipping glucocorticoid receptor sodium and hydrogen exchanger 3 sodium transport thiazide-sensitive Na+/Cl– cotransporter

Journal

Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006

Informations de publication

Date de publication:
2019
Historique:
received: 18 03 2019
accepted: 18 07 2019
entrez: 3 9 2019
pubmed: 3 9 2019
medline: 3 9 2019
Statut: epublish

Résumé

Chronic glucocorticoid infusion impairs NCC activity and induces a non-dipping profile in mice, suggesting that glucocorticoids are essential for daily blood pressure variations. In this paper, we studied mice lacking the renal tubular glucocorticoid receptor (GR) in adulthood (GR knockouts,

Identifiants

pubmed: 31474871
doi: 10.3389/fphys.2019.00989
pmc: PMC6702950
doi:

Types de publication

Journal Article

Langues

eng

Pagination

989

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Auteurs

Jérémie Canonica (J)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
National Centre of Competence in Research "Kidney.CH", Lausanne, Switzerland.

Simona Frateschi (S)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
National Centre of Competence in Research "Kidney.CH", Lausanne, Switzerland.

Emilie Boscardin (E)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
National Centre of Competence in Research "Kidney.CH", Lausanne, Switzerland.

Anna Ebering (A)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

Chloé Sergi (C)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

Yannick Jäger (Y)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

Thibaud Peyrollaz (T)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

Anne-Marie Mérillat (AM)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

Marc Maillard (M)

Department of Nephrology Service, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Petra Klusonova (P)

Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Alex Odermatt (A)

National Centre of Competence in Research "Kidney.CH", Lausanne, Switzerland.
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Robert Koesters (R)

Hôpital Tenon, Université Pierre et Marie Curie, Paris, France.

Anne Debonneville (A)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

Olivier Staub (O)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
National Centre of Competence in Research "Kidney.CH", Lausanne, Switzerland.

Sophia N Verouti (SN)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

Edith Hummler (E)

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
National Centre of Competence in Research "Kidney.CH", Lausanne, Switzerland.

Classifications MeSH