Obesity as the Main Risk Factor for Metabolic Syndrome in Children.
childhood & adolescence
insulin resistance
metabolic syndrome (MetS)
obesity
weight loss
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2019
2019
Historique:
received:
18
03
2019
accepted:
02
08
2019
entrez:
3
9
2019
pubmed:
3
9
2019
medline:
3
9
2019
Statut:
epublish
Résumé
Obesity in childhood is the main determinant of whole body reduced insulin sensitivity. This association has been demonstrated in multiple adult and pediatric cohorts. The mechanistic link explaining this association is the pattern of lipid partitioning in the face of excess calories and energy surplus. A tight relation exists between typical lipid deposition patterns, specifically within the skeletal muscle and liver, as well as the intra-abdominal compartment and whole body insulin sensitivity. The impact of lipid deposition within insulin responsive tissues such as the liver and skeletal muscle relates to the ability of fatty acid derivates to inhibit elements of the insulin signal transduction pathway. Strengthening the relation of obesity and reduced insulin sensitivity are the observations that weight gain reduces insulin sensitivity while weight loss increases it. This manifests as the appearance of cardiovascular risk factor clustering with weight gain and its recovery in the face of weight loss. Both obesity
Identifiants
pubmed: 31474943
doi: 10.3389/fendo.2019.00568
pmc: PMC6706788
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
568Références
Arch Intern Med. 1999 May 24;159(10):1104-9
pubmed: 10335688
J Clin Invest. 2000 Jul;106(2):171-6
pubmed: 10903330
Sports Med. 2000 Dec;30(6):405-22
pubmed: 11132123
Diabetes. 2001 Nov;50(11):2444-50
pubmed: 11679420
Diabetes. 2002 Apr;51(4):1022-7
pubmed: 11916921
Circulation. 2002 Jul 16;106(3):286-8
pubmed: 12119239
Diabetes Care. 2002 Aug;25(8):1351-7
pubmed: 12145234
J Lipid Res. 2002 Sep;43(9):1363-79
pubmed: 12235168
Diabetes. 2003 May;52(5):1210-4
pubmed: 12716754
JAMA. 2003 May 21;289(19):2560-72
pubmed: 12748199
N Engl J Med. 2004 Feb 12;350(7):664-71
pubmed: 14960743
Arch Intern Med. 2004 May 24;164(10):1066-76
pubmed: 15159263
N Engl J Med. 2004 Jun 3;350(23):2362-74
pubmed: 15175438
Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E741-7
pubmed: 15562250
Diabetes Care. 2005 Apr;28(4):902-9
pubmed: 15793193
J Clin Endocrinol Metab. 2005 Jun;90(6):3731-7
pubmed: 15797955
Circulation. 2005 Oct 25;112(17):2735-52
pubmed: 16157765
J Pediatr. 2007 Jan;150(1):12-17.e2
pubmed: 17188605
Diabetes. 2007 Jul;56(7):1761-72
pubmed: 17456850
Eur J Endocrinol. 2007 Aug;157 Suppl 1:S39-45
pubmed: 17785696
Pediatr Diabetes. 2007 Oct;8(5):299-306
pubmed: 17850473
Horm Metab Res. 2007 Oct;39(10):707-9
pubmed: 17952830
J Pediatr. 2008 Feb;152(2):165-70
pubmed: 18206683
Atherosclerosis. 2009 Nov;207(1):174-80
pubmed: 19442975
Pediatr Diabetes. 2009 Sep;10(6):360-7
pubmed: 19490496
Diabetes Care. 2009 Oct;32(10):1910-5
pubmed: 19587363
Diabetes Care. 2009 Nov;32(11):2114-5
pubmed: 19675204
J Am Coll Cardiol. 2009 Dec 15;54(25):2396-406
pubmed: 20082930
J Clin Endocrinol Metab. 2010 Dec;95(12):5189-98
pubmed: 20829185
Pediatrics. 2011 Mar;127(3):402-10
pubmed: 21300674
Diabetes. 2011 Nov;60(11):2802-9
pubmed: 22025778
Ann N Y Acad Sci. 2013 Apr;1281:123-40
pubmed: 23356701
Physiol Rev. 2013 Jul;93(3):993-1017
pubmed: 23899560
Diabetes Care. 2014 Feb;37(2):317-24
pubmed: 24062325
Endocrinol Metab Clin North Am. 2014 Mar;43(1):75-102
pubmed: 24582093
Curr Diab Rep. 2014 Jun;14(6):493
pubmed: 24743942
JAMA Pediatr. 2014 Sep;168(9):807-14
pubmed: 25022831
Int J Obes (Lond). 2014 Sep;38 Suppl 2:S4-14
pubmed: 25376220
N Engl J Med. 2015 Oct;373(14):1307-17
pubmed: 26422721
N Engl J Med. 2016 Jan 14;374(2):113-23
pubmed: 26544725
BMC Pediatr. 2015 Dec 30;15:196
pubmed: 26714769
J Clin Invest. 2016 Jan;126(1):12-22
pubmed: 26727229
J Clin Endocrinol Metab. 2016 Jun;101(6):2423-31
pubmed: 27054297
Curr Diab Rep. 2016 Jul;16(7):64
pubmed: 27179965
J Clin Endocrinol Metab. 2016 Aug;101(8):3088-95
pubmed: 27218274
J Clin Endocrinol Metab. 2016 Aug;101(8):3171-9
pubmed: 27285295
Endocr Rev. 2016 Oct;37(5):467-520
pubmed: 27459230
Nutrients. 2016 Oct 01;8(10):
pubmed: 27706073
Lancet Diabetes Endocrinol. 2017 Mar;5(3):174-183
pubmed: 28065734
Acad Radiol. 2017 Aug;24(8):982-987
pubmed: 28462823
Pediatr Diabetes. 2018 May;19(3):366-374
pubmed: 29159854
J Pediatr. 2018 Jan;192:105-114
pubmed: 29246331
Pediatrics. 2018 Feb;141(2):
pubmed: 29311357
Physiol Rev. 2018 Oct 1;98(4):2133-2223
pubmed: 30067154
Diab Vasc Dis Res. 2019 Mar;16(2):153-159
pubmed: 31014093
Diabetes. 1967 Jul;16(7):478-82
pubmed: 6028756
Physiol Rev. 1995 Jul;75(3):473-86
pubmed: 7624391
Metabolism. 1996 Feb;45(2):235-40
pubmed: 8596496