Algorithms
Animals
Antibodies, Neutralizing
/ immunology
Coinfection
/ immunology
Cytokines
/ immunology
Female
Humans
Influenza A virus
/ immunology
Interferon-gamma
/ immunology
Interleukin-6
/ immunology
Lung
/ immunology
Mice, Inbred C57BL
Models, Immunological
Neutralization Tests
Orthomyxoviridae Infections
/ immunology
Pneumococcal Infections
/ immunology
Pneumonia
/ immunology
Streptococcus pneumoniae
/ immunology
IFN-γ neutralization
IL-6 neutralization
Influenza Virus
Streptococcus pneumoniae
co-infection
mathematical modeling
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
03
2019
accepted:
23
07
2019
entrez:
3
9
2019
pubmed:
3
9
2019
medline:
6
10
2020
Statut:
epublish
Résumé
An overt pro-inflammatory immune response is a key factor contributing to lethal pneumococcal infection in an influenza pre-infected host and represents a potential target for therapeutic intervention. However, there is a paucity of knowledge about the level of contribution of individual cytokines. Based on the predictions of our previous mathematical modeling approach, the potential benefit of IFN-γ- and/or IL-6-specific antibody-mediated cytokine neutralization was explored in C57BL/6 mice infected with the influenza A/PR/8/34 strain, which were subsequently infected with the
Identifiants
pubmed: 31474978
doi: 10.3389/fimmu.2019.01864
pmc: PMC6702285
doi:
Substances chimiques
Antibodies, Neutralizing
0
Cytokines
0
Interleukin-6
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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