Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis.
imiquimod
neutrophil
platelet
platelet-neutrophil complexes (PNCs)
psoriasis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
01
2019
accepted:
23
07
2019
entrez:
3
9
2019
pubmed:
3
9
2019
medline:
7
10
2020
Statut:
epublish
Résumé
Psoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily by skin lesions with massive infiltration of leukocytes, but frequently also presents with cardiovascular comorbidities. Especially polymorphonuclear neutrophils (PMNs) abundantly infiltrate psoriatic skin but the cues that prompt PMNs to home to the skin are not well-defined. To identify PMN surface receptors that may explain PMN skin homing in psoriasis patients, we screened 332 surface antigens on primary human blood PMNs from healthy donors and psoriasis patients. We identified platelet surface antigens as a defining feature of psoriasis PMNs, due to a significantly increased aggregation of neutrophils and platelets in the blood of psoriasis patients. Similarly, in the imiquimod-induced experimental
Identifiants
pubmed: 31474979
doi: 10.3389/fimmu.2019.01867
pmc: PMC6706802
doi:
Substances chimiques
Imiquimod
P1QW714R7M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1867Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR069502
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073665
Pays : United States
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