Updates on Treatment Approaches for Cutaneous Field Cancerization.
Field cancerization
actinic keratosis
cutaneous squamous cell carcinoma
photodamage
photodynamic therapy
Journal
Current dermatology reports
ISSN: 2162-4933
Titre abrégé: Curr Dermatol Rep
Pays: United States
ID NLM: 101599509
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
entrez:
3
9
2019
pubmed:
3
9
2019
medline:
3
9
2019
Statut:
ppublish
Résumé
Field cancerization describes the phenomenon that multiple heterogenous mutations may arise in an area exposed to chronic carcinogenic stimuli. Advances in the understanding of cutaneous field cancerization have led to novel therapeutic approaches to the management of actinic keratoses (AKs). Herein, we review the literature on the pathophysiology and emerging research of field cancerization in dermatology. The classification systems for grading AK lesions are being refined with investigations focusing on their clinical utility. There is a growing shift towards field-directed treatment for AKs as the importance of field cancerization becomes clearer. Current field-directed therapies are being optimized and novel therapeutic modalities are being studied. Field cancerization underlies the transformation of photodamaged skin into AKs and potentially cutaneous SCC (cSCC). Clinically meaningful classification systems for AKs are needed to better inform decisions regarding treatment. As we learn more about the role of field characterization in photodamage, AKs and cSCCs, therapeutic strategies are becoming more field-directed rather than lesion-directed.
Identifiants
pubmed: 31475077
doi: 10.1007/s13671-019-00265-2
pmc: PMC6716609
mid: NIHMS1047077
doi:
Types de publication
Journal Article
Langues
eng
Pagination
122-132Subventions
Organisme : NIGMS NIH HHS
ID : K23 GM117309
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest Alisen Huang, Evan Austin, Andrew Mamalis, and Jared Jagdeo received grants from Sun Pharmaceutical Industries Ltd. Dr. Jagdeo also received personal fees from Biofrontera. Julie K. Nguyen declares no conflict of interest.
Références
Cancer Res. 2003 Apr 15;63(8):1727-30
pubmed: 12702551
Biochem Biophys Res Commun. 2003 Jul 11;306(4):1026-36
pubmed: 12821146
Cancer. 1953 Sep;6(5):963-8
pubmed: 13094644
Toxicol Appl Pharmacol. 2004 Mar 15;195(3):298-308
pubmed: 15020192
Biochem Pharmacol. 2005 Dec 19;71(1-2):42-9
pubmed: 16288996
J Drugs Dermatol. 2006 Feb;5(2):140-54
pubmed: 16485882
Br J Dermatol. 2007 May;156 Suppl 3:8-12
pubmed: 17488400
Dermatol Surg. 2007 Sep;33(9):1099-101
pubmed: 17760601
Br J Dermatol. 2008 Apr;158(4):740-6
pubmed: 18294318
J Am Acad Dermatol. 2008 May;58(5):719-37; quiz 738-40
pubmed: 18423256
J Am Acad Dermatol. 1991 May;24(5 Pt 1):738-43
pubmed: 1869646
Cancer. 2009 Jun 1;115(11):2523-30
pubmed: 19382202
Int J Dermatol. 2010 Sep;49(9):978-86
pubmed: 20883261
J Dermatol Sci. 2011 Aug;63(2):83-92
pubmed: 21612892
Pigment Cell Melanoma Res. 2011 Aug;24(4):618-30
pubmed: 21762468
Head Neck Oncol. 2011 Dec 22;3:53
pubmed: 22192485
Clin Interv Aging. 2013;8:29-35
pubmed: 23345970
BMC Cancer. 2013 Feb 05;13:58
pubmed: 23379751
Br J Dermatol. 2013 Sep;169(3):502-18
pubmed: 23647091
Int J Dermatol. 2014 Jun;53(6):723-30
pubmed: 24168163
J Cosmet Laser Ther. 2014 Apr;16(2):69-76
pubmed: 24215422
Br J Dermatol. 2014 Jul;171(1):175-8
pubmed: 24506809
Br J Dermatol. 2014 Nov;171(5):1164-71
pubmed: 24861492
Nat Genet. 2014 Oct;46(10):1060-2
pubmed: 25194279
Photodermatol Photoimmunol Photomed. 2015 Jan;31(1):57-60
pubmed: 25377545
J Eur Acad Dermatol Venereol. 2015 May;29(5):991-7
pubmed: 25428612
Curr Probl Dermatol. 2015;46:115-21
pubmed: 25561215
J Eur Acad Dermatol Venereol. 2015 Aug;29(8):1598-605
pubmed: 25640401
Dermatol Surg. 2015 Mar;41(3):387-9
pubmed: 25742561
J Eur Acad Dermatol Venereol. 2015 Oct;29(10):1926-32
pubmed: 25809617
Arch Dermatol Res. 2015 Aug;307(6):515-22
pubmed: 25832754
JAMA Dermatol. 2015 Oct;151(10):1081-6
pubmed: 25928283
Acta Derm Venereol. 2016 Jan;96(1):17-22
pubmed: 26068001
JAMA Dermatol. 2015 Nov;151(11):1220-5
pubmed: 26177278
J Eur Acad Dermatol Venereol. 2015 Dec;29(12):2342-8
pubmed: 26435363
Dermatol Surg. 2015 Nov;41(11):1290-5
pubmed: 26445287
N Engl J Med. 2015 Oct 22;373(17):1618-26
pubmed: 26488693
J Am Acad Dermatol. 2016 Feb;74(2):387-9
pubmed: 26775785
Biochem J. 2016 Feb 15;473(4):347-64
pubmed: 26862179
Br J Dermatol. 2016 Oct;175(4):696-705
pubmed: 26921093
Br J Dermatol. 2016 Sep;175(3):512-9
pubmed: 26931503
Exp Dermatol. 2016 Dec;25(12):997-999
pubmed: 27194644
PLoS One. 2016 Jun 27;11(6):e0157898
pubmed: 27347879
Cutis. 2016 Jun;97(6):415-20
pubmed: 27416085
Dermatol Ther (Heidelb). 2016 Dec;6(4):599-626
pubmed: 27503482
Eur J Dermatol. 2017 Feb 1;27(1):89-91
pubmed: 27748261
J Clin Invest. 2017 Jan 3;127(1):106-116
pubmed: 27869649
Int J Mol Sci. 2016 Dec 08;17(12):
pubmed: 27941650
Br J Dermatol. 2017 May;176(5):1155-1161
pubmed: 28012181
Br J Dermatol. 2017 Jun;176(6):1456-1464
pubmed: 28078678
J Am Acad Dermatol. 2017 Feb;76(2):349-350
pubmed: 28088998
J Am Acad Dermatol. 2017 May;76(5):958-972.e2
pubmed: 28259441
J Eur Acad Dermatol Venereol. 2017 Mar;31 Suppl 2:8-11
pubmed: 28263021
J Dermatolog Treat. 2017 Nov;28(7):652-658
pubmed: 28264612
Lasers Surg Med. 2017 Aug;49(6):592-598
pubmed: 28370019
Head Neck. 2017 Jul;39(7):1462-1469
pubmed: 28370784
Dermatol Surg. 2017 Aug;43(8):1053-1064
pubmed: 28394858
J Eur Acad Dermatol Venereol. 2017 Aug;31(8):1295-1302
pubmed: 28401585
Acta Derm Venereol. 2017 Aug 31;97(8):997-998
pubmed: 28448101
JAMA Dermatol. 2017 Jul 1;153(7):637-643
pubmed: 28514458
Acta Derm Venereol. 2017 Oct 2;97(9):1108-1113
pubmed: 28536731
J Eur Acad Dermatol Venereol. 2018 Jan;32(1):e37-e39
pubmed: 28695987
J Eur Acad Dermatol Venereol. 2018 May;32(5):745-751
pubmed: 28796914
Oxf Med Case Reports. 2017 Aug 10;2017(8):omx043
pubmed: 28845237
J Eur Acad Dermatol Venereol. 2018 Apr;32(4):595-600
pubmed: 28972663
Dermatol Surg. 2018 Apr;44(4):528-533
pubmed: 29053537
J Eur Acad Dermatol Venereol. 2018 Apr;32(4):544-563
pubmed: 29055153
Adv Exp Med Biol. 2017;996:207-219
pubmed: 29124702
J Am Acad Dermatol. 2018 Apr;78(4):795-797
pubmed: 29138062
J Dtsch Dermatol Ges. 2018 Jan;16(1):7-13
pubmed: 29211323
Photomed Laser Surg. 2018 Mar;36(3):174-176
pubmed: 29227199
Dermatol Ther (Heidelb). 2018 Mar;8(1):137-141
pubmed: 29322431
Drug Saf Case Rep. 2018 Jan 12;5(1):4
pubmed: 29330682
J Cutan Med Surg. 2018 May/Jun;22(3):267-272
pubmed: 29351725
J Clin Aesthet Dermatol. 2017 Dec;10(12):19-26
pubmed: 29399263
Photodiagnosis Photodyn Ther. 2018 Jun;22:7-13
pubmed: 29471147
Br J Dermatol. 2018 Oct;179(4):829-835
pubmed: 29476546
J Dermatol Sci. 2018 Jun;90(3):295-302
pubmed: 29530340
Am J Clin Dermatol. 2018 Aug;19(4):543-557
pubmed: 29582369
Photochem Photobiol. 2018 Sep;94(5):1049-1057
pubmed: 29663426
Lasers Surg Med. 2018 Jul;50(5):576-589
pubmed: 29667728
J Dermatol Sci. 2018 May 17;:null
pubmed: 29779986
Cutis. 2018 May;101(5):355-360
pubmed: 29894524
F1000Res. 2018 Jun 1;7:null
pubmed: 29904586
Acta Derm Venereol. 2018 Jul 11;98(7):689-693
pubmed: 29963684
Photodiagnosis Photodyn Ther. 2018 Sep;23:273-280
pubmed: 30030167
Dermatol Ther (Heidelb). 2018 Sep;8(3):455-462
pubmed: 30054800
Expert Opin Drug Metab Toxicol. 2018 Sep;14(9):911-918
pubmed: 30074409
Br J Dermatol. 2019 Apr;180(4):756-764
pubmed: 30117140
J Dtsch Dermatol Ges. 2018 Aug;16(8):1002-1013
pubmed: 30117703
Sci Rep. 2018 Aug 22;8(1):12599
pubmed: 30135507
Expert Opin Pharmacother. 2018 Oct;19(15):1693-1704
pubmed: 30222011
J Dtsch Dermatol Ges. 2018 Oct;16(10):1211-1217
pubmed: 30248236
J Clin Aesthet Dermatol. 2018 Sep;11(9):28-31
pubmed: 30319728
JAMA Dermatol. 2018 Nov 1;154(11):1281-1285
pubmed: 30326488