Impact of Cancer-Associated Fibroblast on the Radiation-Response of Solid Xenograft Tumors.
cancer therapy
cancer-associated fibroblast
fibroblast
radiation resistance
radiation therapy
tumor microenvironment
tumor stoma
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
06
2019
accepted:
29
07
2019
entrez:
3
9
2019
pubmed:
3
9
2019
medline:
3
9
2019
Statut:
epublish
Résumé
Increasing evidence indicates that the heterogeneous tumor stroma supports therapy resistance at multiple levels. Fibroblasts, particularly cancer-associated fibroblasts (CAFs) are critical components of the tumor stroma. However, the impact of CAFs on the outcome of radiotherapy (RT) is poorly understood. Here, we investigated if and how fibroblasts/CAFs modulate the radiation response of malignant tumors by altering cancer cell radiosensitivity or radioresistance
Identifiants
pubmed: 31475157
doi: 10.3389/fmolb.2019.00070
pmc: PMC6705217
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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