Mesoderm specification and diversification: from single cells to emergent tissues.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
03
06
2019
revised:
16
07
2019
accepted:
30
07
2019
pubmed:
3
9
2019
medline:
15
4
2020
entrez:
3
9
2019
Statut:
ppublish
Résumé
The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including the musculoskeletal system (bone, cartilage and muscle), cardiovascular system (heart, blood and blood vessels), as well as the connective tissues found throughout our bodies. A long-standing question pertains how this panoply of mesodermal cell types arises in a stereotypical fashion in time and space. This review discusses the events associated with mesoderm specification, highlighting the reconstruction of putative developmental trajectories facilitated by recent single-cell 'omic' data. We will also discuss the potential of emergent organoid systems to emulate and interrogate the dynamics of lineage specification at cellular resolution.
Identifiants
pubmed: 31476530
pii: S0955-0674(19)30049-3
doi: 10.1016/j.ceb.2019.07.012
pmc: PMC6910985
mid: NIHMS1536646
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110-116Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK084391
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD094868
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Références
Elife. 2018 Feb 07;7:
pubmed: 29412136
Mech Dev. 1997 Nov;68(1-2):3-25
pubmed: 9431800
Nature. 1995 Feb 2;373(6513):432-4
pubmed: 7830794
Nat Methods. 2014 Aug;11(8):847-54
pubmed: 24973948
Development. 2019 Jun 24;146(12):
pubmed: 31152001
Nature. 2018 Oct;562(7726):272-276
pubmed: 30283134
Development. 2003 Sep;130(17):4217-27
pubmed: 12874139
Semin Cell Dev Biol. 2015 Dec;47-48:88-91
pubmed: 26474539
Nat Rev Genet. 2005 Nov;6(11):826-35
pubmed: 16304598
Nat Rev Mol Cell Biol. 2009 Feb;10(2):91-103
pubmed: 19129791
Development. 2014 Nov;141(22):4231-42
pubmed: 25371360
Development. 2007 Aug;134(15):2829-40
pubmed: 17611225
Dev Dyn. 2016 May;245(5):547-57
pubmed: 26845388
Development. 2017 Mar 15;144(6):976-985
pubmed: 28292844
Elife. 2014 Oct 08;3:null
pubmed: 25296024
Nature. 2019 Jun;570(7759):77-82
pubmed: 31086336
PLoS Biol. 2014 Aug 26;12(8):e1001937
pubmed: 25157815
Dev Cell. 2019 Mar 25;48(6):751-763
pubmed: 30913407
Nat Rev Cardiol. 2018 Nov;15(11):705-724
pubmed: 30266935
Nat Commun. 2018 Nov 19;9(1):4877
pubmed: 30451828
Development. 1997 May;124(9):1631-42
pubmed: 9165112
Curr Gene Ther. 2013 Apr;13(2):99-110
pubmed: 23444871
Nature. 2019 Feb;566(7745):490-495
pubmed: 30787436
Nat Commun. 2018 Dec 17;9(1):5345
pubmed: 30559361
Dev Cell. 2016 Nov 7;39(3):302-315
pubmed: 27746044
Dev Cell. 2017 May 8;41(3):243-261.e7
pubmed: 28457792
Int J Dev Biol. 2018;62(11-12):837-846
pubmed: 30604853
Nat Cell Biol. 2018 Feb;20(2):127-134
pubmed: 29311656
Development. 1999 Nov;126(21):4691-701
pubmed: 10518487
Nat Biotechnol. 2015 Nov;33(11):1165-72
pubmed: 26458175
Nat Protoc. 2017 Mar;12(3):534-547
pubmed: 28182018
Science. 2018 Jun 1;360(6392):981-987
pubmed: 29700229
Development. 1999 Aug;126(15):3437-47
pubmed: 10393122
Curr Biol. 2005 Jun 21;15(12):R468-70
pubmed: 15964269
Trends Cardiovasc Med. 2003 Aug;13(6):254-9
pubmed: 12922023
Dev Cell. 2016 Mar 21;36(6):681-97
pubmed: 27003939
Elife. 2015 Feb 26;4:null
pubmed: 25719209
Nature. 2018 Jun;558(7708):132-135
pubmed: 29795348
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
J Am Soc Nephrol. 2005 Jun;16(6):1632-44
pubmed: 15843474
Curr Top Dev Biol. 2018;128:365-390
pubmed: 29477169
Nat Protoc. 2018 Nov;13(11):2685-2713
pubmed: 30353175
Dev Cell. 2009 Sep;17(3):365-76
pubmed: 19758561
Science. 2018 Mar 9;359(6380):1177-1181
pubmed: 29371425
Nature. 2016 Jul 06;535(7611):289-293
pubmed: 27383781
Int J Dev Biol. 2003;47(7-8):531-9
pubmed: 14756329
Science. 2018 Aug 31;361(6405):
pubmed: 30093604
Development. 2002 Oct;129(20):4855-66
pubmed: 12361976
Blood. 1994 Mar 1;83(5):1200-8
pubmed: 8118024
Annu Rev Cell Dev Biol. 2012;28:687-717
pubmed: 22804578
Development. 2019 Jan 2;146(1):
pubmed: 30559277
Cardiovasc Res. 2004 Aug 1;63(2):196-207
pubmed: 15249177
Nat Biotechnol. 2015 May;33(5):495-502
pubmed: 25867923