GDF-15, a mitochondrial disease biomarker, is associated with the severity of multiple sclerosis.
Adult
Age Factors
Aged
Aged, 80 and over
Amyotrophic Lateral Sclerosis
/ blood
Biomarkers
/ blood
Disability Evaluation
Female
Fibroblast Growth Factors
/ blood
Growth Differentiation Factor 15
/ blood
Humans
Limbic Encephalitis
/ blood
Male
Middle Aged
Mitochondrial Diseases
/ blood
Multiple Sclerosis
/ blood
Neuromyelitis Optica
/ blood
Young Adult
Biomarker
FGF-21
GDF-15
Mitochondria disorders
Multiple sclerosis
Neuromyelitis optica spectrum disorders
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 Oct 2019
15 Oct 2019
Historique:
received:
02
02
2019
revised:
14
08
2019
accepted:
14
08
2019
pubmed:
3
9
2019
medline:
15
9
2020
entrez:
3
9
2019
Statut:
ppublish
Résumé
GDF-15, a member of the transforming growth factor beta superfamily, regulates inflammatory and apoptotic pathways in various diseases, such as heart failure, kidney dysfunction, and cancer. We aimed to clarify potentially confounding variables affecting GDF-15 and demonstrate its utility as a mitochondrial biomarker using serum samples from 15 patients with mitochondrial diseases (MD), 15 patients with limbic encephalitis (LE), 10 patients with multiple sclerosis/neuromyelitis optica spectrum disorders (MS/NMOSD), and 19 patients with amyotrophic lateral sclerosis (ALS). GDF-15 and FGF-21 were significantly elevated in MD. GDF-15 and FGF-21 showed a good correlation in MD but not in LE, MS, and ALS. GDF-15 was potentially influenced by age in LE, MS/NMOSD, and ALS but not in MD. FGF-21 was not correlated with age in MS/NMOSD, ALS, LE, and MD. GDF-15 was not correlated with clinical features in LE or BMI or body weight in ALS. GDF-15 positively correlated with the Expanded Disability Status Scale (EDSS) in MS/NMOSD, while EDSS showed no correlation with age. In conclusion, the results revealed that GDF-15 may be influenced by EDSS in MS/NMOPSD and by age in LE, MS/NMOSD, and ALS but not in MD. Mitochondrial damage in MS/NMOSD is a potentially confounding variable affecting GDF-15.
Identifiants
pubmed: 31476622
pii: S0022-510X(19)30361-2
doi: 10.1016/j.jns.2019.116429
pii:
doi:
Substances chimiques
Biomarkers
0
GDF15 protein, human
0
Growth Differentiation Factor 15
0
fibroblast growth factor 21
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116429Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.