Extracellular fluid volume is associated with incident end-stage kidney disease and mortality in patients with chronic kidney disease.
Adult
Aged
Disease Progression
Extracellular Fluid
/ physiology
Female
Glomerular Filtration Rate
/ physiology
Humans
Incidence
Kidney Failure, Chronic
/ epidemiology
Male
Middle Aged
Prognosis
Prospective Studies
Renal Insufficiency, Chronic
/ complications
Risk Factors
Water-Electrolyte Imbalance
/ etiology
Young Adult
chronic kidney disease
extracellular fluid volume
sodium
volume overload
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
02
2019
revised:
14
05
2019
accepted:
07
06
2019
pubmed:
4
9
2019
medline:
21
10
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
Volume overload has been shown to be an independent risk factor for mortality in patients receiving chronic dialysis, but data in non-dialysis patients are scarce. Therefore we evaluated the prognostic value of extracellular fluid (ECF) volume for chronic kidney disease (CKD) progression and mortality in a prospective hospital-based cohort with CKD stage 1-4 (NephroTest Study). ECF (scaled to body surface area) and the measured glomerular filtration rate (mGFR) were determined using the distribution volume and clearance of 51Cr-EDTA, respectively. Cause-specific Cox and linear mixed-effect regression models were used to analyze the association of ECF with end-stage kidney disease (ESKD) and mortality, and with mGFR decline, respectively. The 1593 patients were mean age 58.8 years, 67% were men, mean mGFR of 43.6 mL/min/1.73m
Identifiants
pubmed: 31477263
pii: S0085-2538(19)30704-5
doi: 10.1016/j.kint.2019.06.017
pii:
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1020-1029Investigateurs
François Vrtovsnik
(F)
Eric Daugas
(E)
Nahid Tabibzadeh
(N)
Martin Flamant
(M)
Emmanuelle Vidal-Petiot
(E)
Alexandre Karras
(A)
Stéphane Roueff
(S)
Eric Thervet
(E)
Pascal Houillier
(P)
Marie Courbebaisse
(M)
Caroline Prot-Bertoye
(C)
Jean-Philippe Bertocchio
(JP)
Gérard Maruani
(G)
Jean-Jacques Boffa
(JJ)
Pierre Ronco
(P)
Hafedh Fessi
(H)
Eric Rondeau
(E)
Marine Livrozet
(M)
Emmanuel Letavernier
(E)
Jean-Philippe Haymann
(JP)
Marie Metzger
(M)
Pablo Urena-Torres
(P)
Bénédicte Stengel
(B)
Informations de copyright
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.