Sensitization to grass allergens: Phl p1, Phl p5 and Phl p7 Phl p12 in adult and children patients in Beja (Southern Portugal).
Adolescent
Adult
Aged
Allergens
/ immunology
Antigens, Plant
/ immunology
Biomarkers
Calcium-Binding Proteins
/ immunology
Child
Child, Preschool
Female
Humans
Immunization
/ statistics & numerical data
Immunoglobulin E
/ metabolism
Male
Middle Aged
Plant Proteins
/ immunology
Pollen
/ immunology
Portugal
/ epidemiology
Profilins
/ immunology
Rhinitis, Allergic, Seasonal
/ epidemiology
Young Adult
Grass allergy
Molecular allergens
Phl p 1
Phl p 5
Phl p12
Phl p7
Portugal
Journal
Allergologia et immunopathologia
ISSN: 1578-1267
Titre abrégé: Allergol Immunopathol (Madr)
Pays: Singapore
ID NLM: 0370073
Informations de publication
Date de publication:
Historique:
received:
26
12
2018
revised:
21
04
2019
accepted:
29
04
2019
pubmed:
4
9
2019
medline:
4
4
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
In Portugal, the pollen types most implicated in respiratory allergy are grasses, olive and parietaria. The knowledge of sensitizations to molecular allergens in children and adults can contribute to better diagnosis and treatment of this pathology. ImmunoCAP singleplex technology was used for molecular allergens and Phadia 250® automatic equipment. g205 (Phl p1); g215 (Phl p5b); g210 (Phl p7); and g212 (Phl p12) allergen determinations were made in 45 patients with positive grass sensitization tests. The majority of patients are sensitized to Phl p1 (91%) and Phl p1+/Phl p5-/Phl p7-/Phl p12- was the most dominant profile (40%). In the adult group, the IgE averages for Phl p1 were approximately 10.46, while they were 8.43 for Phl p5, 0.69 for Phl p7, and 0.06 for Phl p12. In the child group, these values were higher: 22.49, 20.23, 3.89, and 0.35, respectively. For allergens Phl p1, Phl p5, and Phl p7, these differences between the child and adult population were not statistically significant (p=0.754, p=0.806 and p=0.102, respectively), but for Phl p12, a statistically significant difference (p=0.018) was observed. IgE antibodies Phl p1 is the most important allergic marker and sensitivities caused by Phl p12 give rise to higher IgE values in children.
Sections du résumé
BACKGROUND
BACKGROUND
In Portugal, the pollen types most implicated in respiratory allergy are grasses, olive and parietaria. The knowledge of sensitizations to molecular allergens in children and adults can contribute to better diagnosis and treatment of this pathology.
METHODS
METHODS
ImmunoCAP singleplex technology was used for molecular allergens and Phadia 250® automatic equipment. g205 (Phl p1); g215 (Phl p5b); g210 (Phl p7); and g212 (Phl p12) allergen determinations were made in 45 patients with positive grass sensitization tests.
RESULTS
RESULTS
The majority of patients are sensitized to Phl p1 (91%) and Phl p1+/Phl p5-/Phl p7-/Phl p12- was the most dominant profile (40%). In the adult group, the IgE averages for Phl p1 were approximately 10.46, while they were 8.43 for Phl p5, 0.69 for Phl p7, and 0.06 for Phl p12. In the child group, these values were higher: 22.49, 20.23, 3.89, and 0.35, respectively. For allergens Phl p1, Phl p5, and Phl p7, these differences between the child and adult population were not statistically significant (p=0.754, p=0.806 and p=0.102, respectively), but for Phl p12, a statistically significant difference (p=0.018) was observed.
CONCLUSIONS
CONCLUSIONS
IgE antibodies Phl p1 is the most important allergic marker and sensitivities caused by Phl p12 give rise to higher IgE values in children.
Identifiants
pubmed: 31477404
pii: S0301-0546(19)30071-0
doi: 10.1016/j.aller.2019.04.006
pii:
doi:
Substances chimiques
Allergens
0
Antigens, Plant
0
Biomarkers
0
Calcium-Binding Proteins
0
Phl p 12 allergen, timothy grass
0
Phl p 7 allergen
0
Phl p V protein, Phleum pratense
0
Plant Proteins
0
Profilins
0
PHLPI protein, Phleum pratense
160227-82-7
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
579-584Informations de copyright
Copyright © 2019 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.