Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.

Chromosomes, Human, Pair 2 / genetics Cytokines / genetics Female Fetus / metabolism Genome, Human / genetics Genome-Wide Association Study Gestational Age Humans Infant, Newborn Polymorphism, Single Nucleotide Pregnancy Premature Birth / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
02 09 2019
Historique:
received: 08 10 2018
accepted: 05 08 2019
entrez: 4 9 2019
pubmed: 4 9 2019
medline: 31 12 2019
Statut: epublish

Résumé

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P = 3.96 × 10

Identifiants

DOI: 10.1038/s41467-019-11881-8 PMID: 31477735 PMC: PMC6718389
pubmed: 31477735
doi: 10.1038/s41467-019-11881-8
pii: 10.1038/s41467-019-11881-8
pmc: PMC6718389
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3927

Subventions

Organisme : Wellcome Trust
ID : 203141
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS099068
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U01 DK105535
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM055479
Pays : United States
Organisme : Wellcome Trust
ID : 090532
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 093831
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106130
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD091527
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103246
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR070549
Pays : United States

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Auteurs

Xueping Liu (X)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Dorte Helenius (D)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.

Line Skotte (L)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
ORCID: 0000-0002-7398-1271

Robin N Beaumont (RN)

Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
ORCID: 0000-0003-0750-8248

Matthias Wielscher (M)

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

Frank Geller (F)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Julius Juodakis (J)

Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0001-5600-974X

Anubha Mahajan (A)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
ORCID: 0000-0001-5585-3420

Jonathan P Bradfield (JP)

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Quantinuum Research, LLC, San Diego, CA, USA.

Frederick T J Lin (FTJ)

Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
ORCID: 0000-0003-1670-6086

Suzanne Vogelezang (S)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Mariona Bustamante (M)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Tarunveer S Ahluwalia (TS)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-7464-3354

Niina Pitkänen (N)

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.

Carol A Wang (CA)

School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, NSW, Australia.
ORCID: 0000-0002-4301-3974

Jonas Bacelis (J)

Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
ORCID: 0000-0002-2450-732X

Maria C Borges (MC)

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Ge Zhang (G)

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.

Bruce A Bedell (BA)

Department of Pediatrics, University of Iowa, Iowa City, IA, USA.

Robert M Rossi (RM)

March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Kristin Skogstrand (K)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Statens Serum Institut, Center for Neonatal Screening, Department for Congenital Disorders, Copenhagen, Denmark.
ORCID: 0000-0002-0026-3711

Shouneng Peng (S)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.
Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.

Wesley K Thompson (WK)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.

Vivek Appadurai (V)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.

Debbie A Lawlor (DA)

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
NIHR Bristol Biomedical Research Centre, Bristol, UK.
ORCID: 0000-0002-6793-2262

Ilkka Kalliala (I)

Department of Surgery and Cancer, IRDB, Faculty of Medicine, Imperial College, London, W12 0NN, UK.
Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu, 200029 HUS, Finland.
ORCID: 0000-0002-7664-0587

Christine Power (C)

Population, Policy and Practice, Great Ormond Street Institute for Child Health, University College London, London, UK.

Mark I McCarthy (MI)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK.
NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK.
ORCID: 0000-0002-4393-0510

Heather A Boyd (HA)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
ORCID: 0000-0001-6849-9985

Mary L Marazita (ML)

Center for Craniofacial and Dental Genetics, Department of Oral Biology School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Hakon Hakonarson (H)

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0003-2814-7461

M Geoffrey Hayes (MG)

Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Department of Anthropology, Northwestern University, Evanston, IL, USA.
Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Denise M Scholtens (DM)

Division of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Fernando Rivadeneira (F)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0001-9435-9441

Vincent W V Jaddoe (VWV)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0003-2939-0041

Rebecca K Vinding (RK)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Hans Bisgaard (H)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-4131-7592

Bridget A Knight (BA)

NIHR Exeter Clinical Research Facility, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
ORCID: 0000-0002-2073-0487

Katja Pahkala (K)

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.
Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Health and Physical Activity, University of Turku, 20520, Turku, Finland.

Olli Raitakari (O)

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20521, Turku, Finland.

Øyvind Helgeland (Ø)

K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
Norwegian Institute of Public Health, Division of Health data and Digitalization, Department of Genetic Research and Bioinformatics, Oslo, Norway.
ORCID: 0000-0002-5612-2985

Stefan Johansson (S)

K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
ORCID: 0000-0002-2298-7008

Pål R Njølstad (PR)

K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
ORCID: 0000-0003-0304-6728

João Fadista (J)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.

Andrew J Schork (AJ)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.

Ron Nudel (R)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
ORCID: 0000-0003-2309-011X

Daniel E Miller (DE)

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Xiaoting Chen (X)

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Matthew T Weirauch (MT)

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
ORCID: 0000-0001-7977-9122

Preben Bo Mortensen (PB)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.

Anders D Børglum (AD)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.
ORCID: 0000-0001-8627-7219

Merete Nordentoft (M)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Mental Health Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Ole Mors (O)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.

Ke Hao (K)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.
Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.

Kelli K Ryckman (KK)

Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Department of Epidemiology, University of Iowa, Iowa City, IA, USA.

David M Hougaard (DM)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Statens Serum Institut, Center for Neonatal Screening, Department for Congenital Disorders, Copenhagen, Denmark.
ORCID: 0000-0001-5928-3517

Leah C Kottyan (LC)

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
ORCID: 0000-0003-3979-2220

Craig E Pennell (CE)

School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, NSW, Australia.

Leo-Pekka Lyytikainen (LP)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.
Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, 33014, Tampere, Finland.
ORCID: 0000-0002-7200-5455

Klaus Bønnelykke (K)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-2003-1018

Martine Vrijheid (M)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Janine F Felix (JF)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0002-9801-5774

William L Lowe (WL)

Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Struan F A Grant (SFA)

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0003-2025-5302

Elina Hyppönen (E)

Population, Policy and Practice, Great Ormond Street Institute for Child Health, University College London, London, UK.
Australian Centre for Precision Health, University of South Australia Cancer Research Institute, Adelaide, Australia.
South Australian Health and Medical Research Institute, Adelaide, Australia.
ORCID: 0000-0003-3670-9399

Bo Jacobsson (B)

Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
ORCID: 0000-0001-5079-2374

Marjo-Riitta Jarvelin (MR)

Institute of Health Sciences, University of Oulu, Oulu, Finland.
Department of Epidemiology and Biostatistics, School of Public Health, Medical Research Council-Health Protection Agency Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, UK.
ORCID: 0000-0002-2149-0630

Louis J Muglia (LJ)

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
ORCID: 0000-0002-0301-8770

Jeffrey C Murray (JC)

Department of Pediatrics, University of Iowa, Iowa City, IA, USA.

Rachel M Freathy (RM)

Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
ORCID: 0000-0003-4152-2238

Thomas M Werge (TM)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-1829-0766

Mads Melbye (M)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0001-8264-6785

Alfonso Buil (A)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
ORCID: 0000-0002-1863-164X

Bjarke Feenstra (B)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. fee@ssi.dk.
ORCID: 0000-0003-1478-649X

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 1-3 › Chromosomes humains de la paire 2 › Variants in the fetal genome near...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Variants in the fetal genome near...
questionsmedicales.fr › Structures de l'embryon › Foetus › Variants in the fetal genome near...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome humain › Variants in the fetal genome near...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Variants in the fetal genome near...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Âge gestationnel › Variants in the fetal genome near...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Variants in the fetal genome near...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Variants in the fetal genome near...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Variants in the fetal genome near...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Variants in the fetal genome near...
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