Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review.
Body Mass Index
Diabetes Mellitus, Type 2
/ epidemiology
Diet, Healthy
Diet, Western
/ adverse effects
Ethnicity
Gene-Environment Interaction
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide
Prospective Studies
Transcription Factor 7-Like 2 Protein
/ genetics
diet
gene-lifestyle interaction
incident type 2 diabetes
physical activity
weight loss intervention
Journal
Obesity reviews : an official journal of the International Association for the Study of Obesity
ISSN: 1467-789X
Titre abrégé: Obes Rev
Pays: England
ID NLM: 100897395
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
03
05
2019
revised:
26
06
2019
accepted:
08
07
2019
pubmed:
4
9
2019
medline:
11
8
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
The pathophysiological influence of gene-lifestyle interactions on the risk to develop type 2 diabetes (T2D) is currently under intensive research. This systematic review summarizes the evidence for gene-lifestyle interactions regarding T2D incidence. MEDLINE, EMBASE, and Web of Science were systematically searched until 31 January 2019 to identify publication with (a) prospective study design; (b) T2D incidence; (c) gene-diet, gene-physical activity, and gene-weight loss intervention interaction; and (d) population who are healthy or prediabetic. Of 66 eligible publications, 28 reported significant interactions. A variety of different genetic variants and dietary factors were studied. Variants at TCF7L2 were most frequently investigated and showed interactions with fiber and whole grain on T2D incidence. Further gene-diet interactions were reported for, eg, a western dietary pattern with a T2D-GRS, fat and carbohydrate with IRS1 rs2943641, and heme iron with variants of HFE. Physical activity showed interaction with HNF1B, IRS1, PPARγ, ADRA2B, SLC2A2, and ABCC8 variants and weight loss interventions with ENPP1, PPARγ, ADIPOR2, ADRA2B, TNFα, and LIPC variants. However, most findings represent single study findings obtained in European ethnicities. Although some interactions have been reported, their conclusiveness is still low, as most findings were not yet replicated across multiple study populations.
Identifiants
pubmed: 31478326
doi: 10.1111/obr.12921
pmc: PMC8650574
doi:
Substances chimiques
Transcription Factor 7-Like 2 Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1557-1571Subventions
Organisme : Medical Research Council
ID : MC_UU_12015/5
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
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