Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme.
Acetylation
Acetyltransferases
/ chemistry
Animals
Catalytic Domain
Cell Line, Tumor
Coenzyme A
/ chemistry
Enzyme Assays
Escherichia coli
/ genetics
Gene Knockdown Techniques
HEK293 Cells
Histone Acetyltransferases
/ chemistry
Humans
Hydrolases
Mice, Inbred C57BL
Rabbits
TATA-Binding Protein Associated Factors
/ chemistry
Transcription Factor TFIID
/ chemistry
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
21 01 2020
21 01 2020
Historique:
pubmed:
4
9
2019
medline:
14
7
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
The metabolic serine hydrolase family is, arguably, one of the largest functional enzyme classes in mammals, including humans, comprising 1-2% of the total proteome. This enzyme family uses a conserved nucleophilic serine residue in the active site to perform diverse hydrolytic reactions and consists of proteases, lipases, esterases, amidases, and transacylases, which are prototypical members of this family. In humans, this enzyme family consists of >250, of which approximately 40% members remain unannotated, in terms of both their endogenous substrates and the biological pathways that they regulate. The enzyme ABHD14B, an outlying member of this family, is also known as CCG1/TAF
Identifiants
pubmed: 31478652
doi: 10.1021/acs.biochem.9b00703
pmc: PMC6976303
mid: EMS84307
doi:
Substances chimiques
TATA-Binding Protein Associated Factors
0
Transcription Factor TFIID
0
Acetyltransferases
EC 2.3.1.-
Histone Acetyltransferases
EC 2.3.1.48
TATA-binding protein associated factor 250 kDa
EC 2.7.11.1
ABHD14B protein, human
EC 3.-
Hydrolases
EC 3.-
Coenzyme A
SAA04E81UX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
183-196Subventions
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/I/15/2/502058
Pays : India
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