Minimally invasive parathyroid carcinoma-A missing entity between parathyroid adenoma and carcinoma: Scintigraphic and histological features.
Adenoma
/ diagnosis
Adult
Carcinoma
/ diagnosis
Female
Humans
Hyperparathyroidism, Primary
/ diagnosis
Male
Middle Aged
Parathyroid Neoplasms
/ diagnosis
Positron Emission Tomography Computed Tomography
Retrospective Studies
Technetium Tc 99m Sestamibi
/ analysis
Tomography, Emission-Computed, Single-Photon
minimally invasive parathyroid carcinoma
parathyroid adenoma
parathyroid carcinoma
primary hyperparathyroidism
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
12
06
2019
revised:
21
08
2019
accepted:
28
08
2019
pubmed:
4
9
2019
medline:
15
9
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
Minimally invasive parathyroid carcinoma (MIPC) is clinically and biochemically comparable with parathyroid adenoma (PA) though histopathologically differ from PA. MIPC is an intermediate of PA and parathyroid carcinoma (PC). In literature, there is no definite criterion to diagnose MIPC. Our aim was to evaluate and characterize the imaging and biochemical parameters with histological characteristics of MIPC. Ten patients with MIPC were recruited from (single centre) Indian PHPT registry (www.indianphptregistry.com) from January 2014 to July 2018. Clinical, biochemical, imaging and histological features of MIPC patients were reviewed. The mean age of MIPC patients (n = 10; 3 males) was 39.9 ± 11.3 years (range: 17-50). All patients had an elevated preoperative parathyroid hormone (iPTH) level ranging from 427 to 2138 pg/mL (median: 1328). MIBI scan showed intensely avid and enlarged parathyroid tumours in all patients; LIPT in 6, RIPT in 3 and ectopic mediastinal in 1 with mean size of the tumours was 2.8 ± 1.1 cm. The mean of maximum standardized uptake value (SUVmax) of MIPC in F-18 fluorocholine PET/CT was 6.7 ± 1.1 (range 6.0-8.3). The mean tumour weight was 12 ± 9.5 g (range: 1.09-28). All MIPC patients had identified capsular invasion in 80% and vascular invasion in 50% only but there was no local invasion, lymph nodal or distant metastasis. The mean Ki-67 labelling index was 3.2 ± 2.7 (range 1.1-10). The study concluded that MIPC patients are less aggressive (on the basis of imaging and histopathological findings) and should be differentiated from parathyroid adenoma and carcinoma.
Substances chimiques
Technetium Tc 99m Sestamibi
971Z4W1S09
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
842-850Informations de copyright
© 2019 John Wiley & Sons Ltd.
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