Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis.
early neurological deterioration
ischemic stroke
subclinical hyperthyroidism
subclinical hypothyroidism
thrombolysis
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
03 09 2019
03 09 2019
Historique:
received:
07
06
2019
accepted:
14
08
2019
pubmed:
4
9
2019
medline:
22
9
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
Data regarding the association between subclinical thyroid dysfunction and clinical outcomes in ischemic stroke patients with intravenous thrombolysis (IVT) are limited. We aimed to investigate the predictive value of subclinical thyroid dysfunction in END, functional outcome and mortality at 3 months among IVT patients. We prospectively recruited 563 IVT patients from 5 stroke centers in China. Thyroid function status was classified as subclinical hypothyroidism, subclinical hyperthyroidism (SHyper) and euthyroidism. The primary outcome was END, defined as ≥ 4 point in the NIHSS score within 24 h after IVT. Secondary outcomes included 3-month functional outcome and mortality. Of the 563 participants, END occurred in 14.7%, poor outcome in 50.8%, and mortality in 9.4%. SHyper was an independent predictor of END [odd ratio (OR), 4.35; 95% confidence interval [CI], 1.86-9.68,
Identifiants
pubmed: 31479421
doi: 10.18632/aging.102215
pii: 102215
pmc: PMC6756908
doi:
Substances chimiques
Fibrinolytic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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