Exploring the link between tumour metabolism and succinate dehydrogenase deficiency: A
18F-FDOPA
genetics
paragangliomas
radionuclide imaging
succinate dehydrogenase
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
09
07
2019
revised:
20
08
2019
accepted:
26
08
2019
pubmed:
4
9
2019
medline:
15
9
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
Nuclear imaging findings by virtue of phenotyping disease heavily depend on genetic background, metabolites, cell membrane specific targets and signalling pathways. PPGL related to succinate dehydrogenase subunits mutations (SDHx mutations) are less differentiated than other subgroups and therefore may lack to concentrate Retrospective study PATIENTS: A cohort of 86 head and neck PPGL patients (including three metastatic) with normal metanephrines underwent In nonmetastatic HNPGL (50 non-SDHx/33 SDHx), no significant difference was observed between these two groups for SUVmax (P = .256), SUVmean (P = .188), MTV 42% (P = .596) and total lesion uptake (P = .144). Metastatic HNPGL also had high elevated uptake values. Our results suggest that SDH deficiency or metastatic behaviour have no influence on
Identifiants
pubmed: 31479526
doi: 10.1111/cen.14086
pmc: PMC7446860
mid: NIHMS1619674
doi:
Substances chimiques
Succinate Dehydrogenase
EC 1.3.99.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
879-884Subventions
Organisme : Intramural NIH HHS
ID : Z99 HD999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HD008735
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons Ltd.
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