Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice.

Animals Aspartic Acid Endopeptidases / genetics Cysteine Endopeptidases / genetics Dermatitis, Atopic / genetics Disease Models, Animal Elastic Modulus Epidermal Cells / pathology Epidermis / pathology Filaggrin Proteins Humans Intermediate Filament Proteins / deficiency Loss of Function Mutation Mice Mice, Knockout Microscopy, Atomic Force

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
03 2020
Historique:
received: 08 01 2019
revised: 20 06 2019
accepted: 08 07 2019
pubmed: 4 9 2019
medline: 11 11 2020
entrez: 4 9 2019
Statut: ppublish

Résumé

Abundant corneocyte surface protrusions, observed in patients with atopic dermatitis with filaggrin loss-of-function mutations, are inversely associated with levels of natural moisturizing factors (NMFs) in the stratum corneum. To dissect the etiological role of NMFs and filaggrin deficiency in surface texture alterations, we examined mouse models with genetic deficiencies in the synthesis or degradation of filaggrin monomers for NMFs, cell stiffness (elastic modulus) and corneocyte surface protrusion density (dermal texture index). Five neonatal and adult mouse models carrying inactivating mutations of SASPase (Sasp

Identifiants

DOI: 10.1016/j.jid.2019.07.716 PMID: 31479664
pubmed: 31479664
pii: S0022-202X(19)33201-4
doi: 10.1016/j.jid.2019.07.716
pii:
doi:

Substances chimiques

FLG protein, human 0
Filaggrin Proteins 0
Intermediate Filament Proteins 0
Taps protein, mouse 0
Cysteine Endopeptidases EC 3.4.22.-
bleomycin hydrolase EC 3.4.22.40
Aspartic Acid Endopeptidases EC 3.4.23.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

615-623.e5

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Jacob P Thyssen (JP)

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. Electronic address: jacob.p.thyssen@regionh.dk.

Ivone Jakasa (I)

Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia.

Christoph Riethmüller (C)

Serend-ip GmbH, Centre for Nanotechnology, Munster, Germany.

Michael P Schön (MP)

Department of Dermatology, Venereology, and Allergology, University Medical Center, Georg August University, Göttingen, Germany; Lower Saxony Institute of Occupational Dermatology, University Medical Center, Göttingen, Germany.

Andrea Braun (A)

Department of Dermatology, Venereology, and Allergology, University Medical Center, Georg August University, Göttingen, Germany; Lower Saxony Institute of Occupational Dermatology, University Medical Center, Göttingen, Germany.

Marek Haftek (M)

CNRS UMR5305, Laboratory of Tissue Biology and Therapeutic Engineering, Lyon, France.

Padraic G Fallon (PG)

School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Jacek Wróblewski (J)

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, International Center for Public Health, Newark, New Jersey; Institute of Biorganic Chemistry, Polish Academy of Science, Poznań, Poland.

Hieronim Jakubowski (H)

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, International Center for Public Health, Newark, New Jersey; Department of Biochemistry and Biotechnology, University of Life Sciences, Poznań, Poland.

Leopold Eckhart (L)

Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Wim Declercq (W)

Molecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Technologiepark 927, Gent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

Sjors Koppes (S)

Amsterdam UMC, University of Amsterdam, Coronel Institute of Occupational Health, Amsterdam Public Health research institute, Amsterdam, Netherlands.

Kristiane A Engebretsen (KA)

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Charlotte Bonefeld (C)

Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Alan D Irvine (AD)

Paediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; Clinical Medicine, Trinity College Dublin, Dublin, Ireland.

Sokhna Keita-Alassane (S)

Laboratory for Epithelial Differentiation and Rheumatoid Autoimmunity, Inserm U1056, University of Toulouse III, Toulouse, France.

Michel Simon (M)

Laboratory for Epithelial Differentiation and Rheumatoid Autoimmunity, Inserm U1056, University of Toulouse III, Toulouse, France.

Hiroshi Kawasaki (H)

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; Disease Biology group, Medical Sciences Innovation Hub Program, Cluster for Science and Technology Hub, RIKEN, Yokohama, Japans; Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Akiharu Kubo (A)

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Masayuki Amagai (M)

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Takeshi Matsui (T)

Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Sanja Kezic (S)

Amsterdam UMC, University of Amsterdam, Coronel Institute of Occupational Health, Amsterdam Public Health research institute, Amsterdam, Netherlands. Electronic address: s.kezic@amc.uva.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Filaggrin Expression and Processing...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Aspartic acid endopeptidases › Filaggrin Expression and Processing...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Cysteine endopeptidases › Filaggrin Expression and Processing...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Eczéma atopique › Filaggrin Expression and Processing...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Filaggrin Expression and Processing...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Élasticité › Module d'élasticité › Filaggrin Expression and Processing...
questionsmedicales.fr › Cellules › Cellules épidermiques › Filaggrin Expression and Processing...
questionsmedicales.fr › Système tégumentaire › Peau › Épiderme › Filaggrin Expression and Processing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines S100 › Protéines filaggrine › Filaggrin Expression and Processing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Filaggrin Expression and Processing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Filaggrin Expression and Processing...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › Filaggrin Expression and Processing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Filaggrin Expression and Processing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Filaggrin Expression and Processing...
questionsmedicales.fr › Techniques d'investigation › Microscopie à sonde à balayage › Microscopie à force atomique › Filaggrin Expression and Processing...