Saturable elimination of piperacillin in critically ill patients: implications for continuous infusion.

Aged Anti-Bacterial Agents / administration & dosage Area Under Curve Computer Simulation Critical Illness Drug Administration Schedule Female Humans Male Middle Aged Piperacillin / administration & dosage
Critically ill Pharmacokinetics Piperacillin Saturation

Journal

International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 19 04 2019
revised: 29 07 2019
accepted: 24 08 2019
pubmed: 4 9 2019
medline: 17 4 2020
entrez: 4 9 2019
Statut: ppublish

Résumé

The study aimed to evaluate saturation of piperacillin elimination in critically ill adult patients. Seventeen critically ill adult patients received continuous and intermittent infusion of piperacillin/tazobactam. Piperacillin plasma concentrations (n = 217) were analysed using population pharmacokinetic (PopPK) modelling. Post-hoc simulations were performed to evaluate the type I error rate associated with the study. Unseen data were used to validate the final model. The mean error (ME) and root mean square error (RMSE) were calculated as a measure of bias and imprecision, respectively. A PopPK model with parallel linear and non-linear elimination best fitted the data. The median and 95% confidence interval (CI) for the model parameters drug clearance (CL), volume of central compartment (V), volume of peripheral compartment (V

Identifiants

DOI: 10.1016/j.ijantimicag.2019.08.024 PMID: 31479741
pubmed: 31479741
pii: S0924-8579(19)30242-0
doi: 10.1016/j.ijantimicag.2019.08.024
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Piperacillin X00B0D5O0E

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

741-749

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

S A M Dhaese (SAM)

Ghent University Hospital, Department of Critical Care Medicine, C. Heymanslaan 10, 9000 Ghent, Belgium. Electronic address: sofie.dhaese@ugent.be.

P Colin (P)

University of Groningen, University Medical Center Groningen, Department of Anesthesiology, Groningen, The Netherlands; Ghent University, Laboratory of Medical Biochemistry and Clinical Analysis, Ghent, Belgium.

H Willems (H)

Ghent University Hospital, Department of Critical Care Medicine, C. Heymanslaan 10, 9000 Ghent, Belgium.

A Heffernan (A)

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; School of Medicine, Griffith University, Southport, QLD, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.

B Gadeyne (B)

Ghent University Hospital, Department of Critical Care Medicine, C. Heymanslaan 10, 9000 Ghent, Belgium.

S Van Vooren (S)

Ghent University, Department of Diagnostic Sciences, Ghent, Belgium.

P Depuydt (P)

Ghent University Hospital, Department of Critical Care Medicine, C. Heymanslaan 10, 9000 Ghent, Belgium.

E Hoste (E)

Ghent University Hospital, Department of Critical Care Medicine, C. Heymanslaan 10, 9000 Ghent, Belgium.

V Stove (V)

Ghent University, Department of Diagnostic Sciences, Ghent, Belgium; Ghent University Hospital, Department of Laboratory Medicine, Ghent, Belgium.

A G Verstraete (AG)

Ghent University, Department of Diagnostic Sciences, Ghent, Belgium; Ghent University Hospital, Department of Laboratory Medicine, Ghent, Belgium.

J Lipman (J)

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Department of Intensive Care Medicine, Brisbane, QLD, Australia; CHU Nîmes, Department of Anesthesiology and Critical Care, Nîmes, France.

J A Roberts (JA)

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Department of Intensive Care Medicine, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Department of Pharmacy, Brisbane, QLD, Australia.

J J De Waele (JJ)

Ghent University Hospital, Department of Critical Care Medicine, C. Heymanslaan 10, 9000 Ghent, Belgium.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Saturable elimination of piperacillin in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Saturable elimination of piperacillin in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › Saturable elimination of piperacillin in...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Saturable elimination of piperacillin in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie grave › Saturable elimination of piperacillin in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Calendrier d'administration des médicaments › Saturable elimination of piperacillin in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Saturable elimination of piperacillin in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Saturable elimination of piperacillin in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Benzylpénicilline › Ampicilline › Pipéracilline › Saturable elimination of piperacillin in...